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Validated xenograft

Not all tumor cell lines are suitable for in vivo drug efficacy study due to either inconsistent tumor take rate or unacceptable large tumor size variation within the same treatment group. Even for tumor cell lines that are well published in the literature, protocols need to be validated for each lab since certain changes in the environment and mouse genetic background may occur, which can change the growth behavior of these models.

In order to provide the highest quality service, we have established a set of stringent criteria to validate our in vivo tumor models. We guarantee the successful establishment of our validated models, and will repeat any study without charge if any of our validated tumor lines failed to establish in nude mice.

List of validated xenograft tumor models:

 
Cancer type
Cell lines
Subcutaneous models  Breast cancer  MCF-7, MCF-7-FL (Her2++), MCF-7-218
  (her2++),MDA-MB231, SKBR3, BT474, SKBR3,
 Lung cancer  A549, NCI-H460, NCI-H226 , SK-MES1, Calu6
 Colorectal cancer  HT-29, HCT-116,DLD-1, SW620, LoVo, Colo205
 Prostate cancer  DU-145, PC-3, LNCaP
 Pancreatic cancer  MIAPACA-2, Bx-PC-3, PANC-1
 Liver cancer  HepG2, SK-HEP-1, Hep3B
 Melanoma  A375, SK-MEL-5
 Ovarian cancer  SKOV3, OVCAR3
 Glioblastoma  U87MG
 Leukemia  K562, HL60
 Multiple myeloma  RPMI 8226  
 Kidney cancer  786-O
 Fibrosarcoma  HT-1080
 Osteosarcoma  143b
 Gastric cancer  MGC803, BGC823, NCI-N87
 H&N cancer  CNE2, KB
Orthotopic models
 Breast cancer  MCF-7, BT474,
 Prostate cancer  LNCaP, Du-145
 Pancreatic cancer  PANC-1, MIAPACA-2
 Leukemia  HL60, RPMI 8226
 Glioblastoma  U87MG
To obtain historical data for each tumor model, please click here
 

>> Primary Tumor Models

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