|
The goal for Crown’s Translational Medicine
Division is to help our customers design the best clinical
strategy for their drug candidates. By working with Crown
and accessing its unique models and powerful molecular profiling
and data analysis capabilities, our customers will significantly
improve their probability of successful clinical development.
More specifically, Crown will help its customers with:
- Clinical compound selection
- Clinical compound indication
- Biomarker strategies
- Patients stratification
- Clinical trial design
To achieve its goals, Crown has developed
an impressive and unique collection of cancer models and assays.
These can be used to select clinical candidate and better
prepare for clinical development. The table below summarizes
Crown Translational Profiling capabilities:
| Models |
Available Currently |
Available in
6 months |
Available in
1 year |
Assay Type |
Throughput |
| Cancer Cells |
110 (total)
27 gastric
16 liver |
300 |
500 |
IC50
Cell Cycle
Apoptosis
Colony formation
Pathway screening |
High |
| Primary Tumors |
450 |
1000 |
2000 |
Colonogenic(TCA) |
Medium |
| Hu_Prime |
100 |
200 |
400 |
Tumor growth inhibition (TGI) |
Low |
|