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Translational Research

The goal for Crown’s Translational Medicine Division is to help our customers design the best clinical strategy for their drug candidates. By working with Crown and accessing its unique models and powerful molecular profiling and data analysis capabilities, our customers will significantly improve their probability of successful clinical development. More specifically, Crown will help its customers with:

  • Clinical compound selection
  • Clinical compound indication
  • Biomarker strategies
  • Patients stratification
  • Clinical trial design

To achieve its goals, Crown has developed an impressive and unique collection of cancer models and assays. These can be used to select clinical candidate and better prepare for clinical development. The table below summarizes Crown Translational Profiling capabilities:

Models Available Currently Available in 6 months Available in 1 year Assay Type Throughput
Cancer Cells 110 (total)
27 gastric
16 liver
300 500 IC50
Cell Cycle
Apoptosis
Colony formation
Pathway screening
High
Primary Tumors 450 1000 2000 Colonogenic(TCA) Medium
Hu_Prime 100 200 400 Tumor growth inhibition (TGI) Low
 

>>  HuPrimeTM 

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