In Vivo

Understand your drug candidates’ potential pharmacological profile using a suite of validated in vivo models. Partner with us to select the most appropriate platform, study design, and screening method tailored to each of your individual drug candidates and research question. Each of our models are supported by a range of translational tools including biomarker, in vitro / ex vivo assays, and in silico modelling to optimize lead candidates.

Patient-Derived Xenograft Models

Leverage our unrivalled collection of PDX models, derived directly from patient tumors to reflect the heterogeneity and diversity of the human patient population

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CDX Models

Make key decisions in a timely and cost-effective manner about the progression of your preclinical development program with cell line-derived xenograft (CDX) models.

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Syngeneic Models

Discover homografts derived from immortalized mouse cancer cell lines with fully competent immunity for assessing single agent and combination immunotherapies.

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Humanized Models

Harness the human immune system against human tumors with human hematopoietic stem cell (HSC) engraftment of patient-derived xenograft models.

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MiXeno™

Explore a simple alternative to the full stem cell reconstitution approach that allows you to evaluate your immunotherapy within a human tumor microenvironment.

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GEMMs

Discover immunocompetent chimeric mouse models, engineered to express humanized drug targets such as genes encoding for immune checkpoint proteins.

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GEMMs - Tumor Homograft (MuPrime™)

Combine the predictive power of GEMM with an improved operational simplicity, consistency, and growth, similar to syngeneic models for your pharmacological research.

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Orthotopics with Advanced Imaging

Explore orthotopic tumor models for clinically relevant research and track tumor progression in real-time using high-frequency ultrasound and bioluminescent imaging.

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