AACR 2023 Posters

29	Characterization of a Murine Intestinal Cancer Homograft Model for Therapeutic Evaluation Session Category: Tumor Biology Authors: Jinxi Wang, Leilei Chen, Likun Zhang, Jingqian Zhu, Ludovic Bourre, Jessie J.J. Wang	Read Poster
52	Characterization of Murine Intrahepatic Cholangiocarcinoma Homograft Models for Therapeutic Evaluation Session Category: Tumor Biology Authors: Jinxi Wang, Leilei Chen, Likun Zhang, Lei Zheng, Ludovic Bourre, Jessie J.J. Wang	Read Poster
185	Global Mapping of Pathway Modules and Phosphorylation Networks in PDX and Corresponding Organoid (PDXO) Models Treated with Targeted Therapies Session Category: Tumor Biology Authors: Martin Mehnert, Xiaoxi Xu, Tobias Treiber, Limei Shang, Leilei Chen, Jessie Wang, Marco Tognetti, Christopher Below, Roland Bruderer, Jakob Vowinckel, Binchen Mao, Wubin Qian, Sheng Guo, Ludovic Bourré, Yuehan Feng	Read Poster
198	Pan-cancer Assay-ready Organoid Drug Screening with Robust, Reproducible and Clinically-relevant Output Session Category: Tumor Biology Authors: Liza Wijler, Jara Garcia Mateos, My Nguyen, Annelot Staes, Linda van Seters, Lama Hasan, Victor Tirouille, Bram Herpers, Leo Price, Mariusz Madej, Michiel Fokkelman, Marrit Putker	Read Poster
401	Developing KRAS G12C Inhibitor-resistant Tumor Models for Efficacy Evaluation of Next-generation Anticancer Therapies Session Category: Experimental and Molecular Therapeutics Authors: Jun Zhou, Zi Ye, Dan Zhang, Aaron Hua, Chenpan Nie, Jessie (Jingjing) Wang, Rajendra Kumari, Leo Price, Xiaoxi Xu	Read Poster
497	HX301, a First-in-class ARK5i, Demonstrates Antitumor Activity in Preclinical HCC Models with High ARK5/Myc Expression Session Category: Experimental and Molecular Therapeutics Authors: Zhihua Jiao, Jessie Wang, Hang Ke, Faming Zhang, and Henry Li	Read Poster
579	Mini-tumors: Preclinical HCI Assays to Screen Anti-cancer Drugs in the Context of Organoids, Cancer-associated Fibroblasts and Immune Cells Session Category: Experimental and Molecular Therapeutics Authors: Marten Hornsveld, Guusje Odenkirchen, Cyrelle van Dort, Jara Garcia, Saskia de Man, Gera Goverse, Bram Herpers, Mariusz Madej, Leo Price, Marrit Putker	Read Poster
2053	Structural Variants Detected by Optical Genome Mapping in Acute Lymphoblastic Leukemia Patient-Derived Xenograft Models Session Category: Bioinformatics / Computational Biology / Systems Biology / Convergent Science Authors: Yueying Wang, Mengting Qing, Jinping Liu, Xiaobo Chen, Jia Xue, Sheng Guo	Read Poster
2387	Characterization of Orthotopic Bioluminescent Patient-derived Xenografts Model of Glioma for Drug Discovery Session Category: Tumor Biology Authors: Jinxi Wang, Ling Chen, Jun Zhou, Likun Zhang, Jinyu Huang, Xueluan Zhu, Ludovic Bourre, Jessie J.J. Wang	Read Poster
2822	Maximizing Radiotherapy Impact: A Novel Preclinical Platform for Screening of Radiosensitizing Agents in Patient-derived Tumor Organoids Session Category: Experimental and Molecular Therapeutics Authors: Liza Wijler, Jara Garcia, Muntaser Abdulrahman, Linda van Seters, My Nguyen, Annelot Staes, Bram Herpers, Leo Price, Marrit Putker	Read Poster
2980	HX009, a First-in-class PD1xCD47 BsAb, Demonstrated Anti-AML Activity in PDX Models Session Category: Immunology Authors: Annie An, Jingping Liu, Hang Ke, Steven Xiong, Xiaolong Tu, Lei Zhang, Faming Zhang, Henry Li	Read Poster
4146	Unlocking IO Drug Potential by High Content Imaging of Immune Cell Co-cultures with Cancer Organoids from Diverse Cancer Indications Session Category: Immunology Authors: Saskia de Man, Chiara Foini, Tomas Veenendaal, Michelle Klop, Christos Sarantaris, Sergei Chavez Abiega, Nataliia Beztsinna, Daniel Okkes, Ashgard Weterings, Leo Price, Gera Goverse	Read Poster
4168	BALB/c-CD3EDG HuGEMM™ Mouse Model for Evaluation of CD3-targeted Tumor Immunotherapy Session Category: Immunology Authors: Demi X. Liu, Kaixia Lian, Xuefei Yan, Jie Lin, Xiaoxi Xu, Annie Xiaoyu An, Ludovic Bourre, Jessie JingJing Wang	Read Poster
4570	Expanding the 3D Ex Vivo Patient Tissue Platform Toolbox for Immuno-Oncology Drug Testing Session Category: Tumor Biology Authors: Nataliia Beztsinna, Sander Basten, Ezgi Kaya Aksoy, Niels Meesters, Stefanos Timiliotis, Donny van der Meer, Kuan Yan, Emma Spanjaard, Willemijn Vader, Leo Price	Read Poster
4679	Molecular Pathology and BTKi Pharmacology of DLBCL PDX Models Session Category: Tumor Biology Authors: Jingjing Wang, Yueying Wang, Wubin Qian, Jia Xue, Sheng Guo, Likun Zhang, Henry Li	Read Poster
5118	STING Agonist and TLR7/8 Agonist Overcome Anti-PD-1 Resistance Mediated by Loss of β2M Session Category: Immunology Authors: Aaron Li Hua, Chenpan Nie, Jie Lin, Annie Xiaoyu An, Ludovic Bourre, Jessie JingJing Wang	Read Poster
6592	An AI Platform for Vascular and Fibrosis Analysis of Pathology Images Session Category: Bioinformatics / Computational Biology / Systems Biology / Convergent Science Authors: Yawen Zheng, Dawei Wang, Likun Zhang, Sheng Guo	Read Poster
6775	Indivumed Services - Combination of Spatial Transcriptomics and Multiplex IHC as Valuable Multi-Omics Tool for Biomarker Discovery Session Category: Biomarkers Authors: Nicole Kerstedt, Monika Schoeppler, Bita Motamedi-Baniassad, Antonia Hirt, Julia Ploetzky, Mirja Kastein, Laura Thoms, Malik Khenkhar, Hartmut Juhl, and Kerstin A. David	Read Poster

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