AAI 23 Poster P892

An in vitro T Cell Dysfunction / Exhaustion Assay System to Non-clinically Assess T Cell-targeting Drug Efficacy

Eden Kleiman^1,2, Linda Liang¹, Gera Goverse¹, and Pirouz Daftarian^1
1Crown Bioscience, ²JSR Life Sciences

The persistence of antigen and chronic stimulation of T cells results in T cells’ functional decay, referred to as T cell dysfunction or exhaustion (TEX). TEX is an essential part of the checks and balances of the immune system chronic T cell stimulation. This poster presents an investigation of an in vitro T cell dysfunction/exhaustion assay to test drug candidates for their ability to delay or partially reverse T cell exhaustion.

Download this Poster to Discover:

• Details on the study method involving repeated stimulation for immunophenotyping and cytokine analysis.
  
  
• Effect of repeated stimulation on co-inhibitory receptors expression in T Cells, cytokine secretion, and cytotoxicity.
  
  
• How this in vitro T cell dysfunction / exhaustion assay can be used as platform to test drug candidates for their ability to delay or reverse T cell exhaustion. 

Download the Poster Now!