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Brain Cancer PDX Models

Suitable preclinical models are needed to evaluate therapies targeting specific pathways which affect brain cancer. Patient-derived xenograft (PDX) models are known to closely reflect human heterogeneity and provide the most accurate approach to predicting an agent’s efficacy prior to entering the clinic. The Crown Bioscience brain cancer PDX collection consists of a wide range of models, including several orthotopic models to more closely recapitulate the tumor microenvironment. More

PDX offer the most translational preclinical model for efficacy screening in cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, PDX models reflect the heterogeneity and diversity of the human patient population. PDX give you an accurate, predictive model of how your treatment will perform, well before entering into expensive clinical trials. Crown Bioscience's HuPrime® PDX models are well characterized for pathology, growth characteristics, and are also genetically/genomically annotated for gene expression, gene copy number, mutations, and fusions.

MODEL NUMBER CANCER TYPE CANCER SUBTYPE DESCRIPTION # per page
BN0769 Brain Cancer Meningeoma Meningeoma CLICK TO VIEW
BN10438 Brain Cancer GBM NA CLICK TO VIEW
BN13331 Brain Cancer Meningeoma Meningioma. Pathol comment: C/W REFERRING DIAGNOSIS. ENTIRE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
BN15385 Brain Cancer GBM N/A CLICK TO VIEW
BN2276 Brain Cancer GBM Pleomorphic glioblastoma of right frontal lobe (WHO grade IV), highly pleomorphic nuclear with irregular form and a few mitoses, microvascular proliferation, haemorrhage, palisading necrosis. CLICK TO VIEW
BN2287 Brain Cancer Glioma Anaplastic oligodendrogliomas (WHO grade III). IHC results: GFAP(+), Ki-67(+ <15%), S-100(-), Syn(-). CLICK TO VIEW
BN2289 Brain Cancer Glioma Anaplastic oligodendrogliomas (WHO grade III). IHC results: GFAP(+), S-100(+), Syn(-), Ki-67(10% +), MMP-9(-), MGMT(-), P53(-), PCNA(+), P170(+). CLICK TO VIEW
BN2331 Brain Cancer Glioma Anaplastic (malignant) meningeoma (WHO grade III). The tumor come from meninx or anfractuosity and infiltrate to brain parenchyma. The tumor show epithelial and fibrous feature. IHC results: GFAP(-), Vim(+++), EMA(+~++), Ki-67(>50%). CLICK TO VIEW
BN2338 Brain Cancer Glioma Astrocytoma, grade II. CLICK TO VIEW
BN3733 Brain Cancer GBM Right frontotemporal area: pleomorphic xanthoastrocytoma, WHO grade II CLICK TO VIEW
BN3801 Brain Cancer NA NA CLICK TO VIEW
BN4027 Brain Cancer Glioma N/A CLICK TO VIEW
BN4045 Brain Cancer GBM NA CLICK TO VIEW
BN5457 Brain Cancer NA Brain Tumor CLICK TO VIEW
BN5459 Brain Cancer NA Meningioma. Atypical menigioma. CLICK TO VIEW
BN5463 Brain Cancer NA Glioblastoma Multiforme CLICK TO VIEW
BN5474 Brain Cancer Glioblastoma Glioblastoma CLICK TO VIEW
BN6299 Brain Cancer Glioma Glioma CLICK TO VIEW
BN6300 Brain Cancer Astrocytoma Glioma CLICK TO VIEW
BN6303 Brain Cancer Glioma NA CLICK TO VIEW
BN6304 Brain Cancer Astrocytoma Occipital lobe of brain: malignant tumor CLICK TO VIEW
BN9224 Brain Cancer GBM NA CLICK TO VIEW

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