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Patient-Derived Xenograft Models of Colorectal Cancer

Robust, well characterized preclinical models are essential for the advancement of targeted therapies for colorectal cancer. Colon cancer patient-derived xenograft (PDX) models display a true representation of the human genetic and phenotypic heterogeneity seen in patient populations and provide the most accurate approach to predicting an agent’s efficacy prior to entering the clinic. Crown Bioscience has one of the largest collections of Colorectal cancer PDX models, including subcutaneous and orthotopic models to more closely recapitulate the tumor microenvironment. More

Benefits of Crown Bioscience's Colon cancer Patient derived xenograft model research

Our Colorectal cancer Patient-derived xenograft models offer the most translational preclinical model for efficacy screening in Colon cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, Patient derived xenograft reflects the heterogeneity and diversity of the human patient population. Colon cancer PDX model will give you an accurate, predictive model of how your treatment will perform, well before entering into expensive clinical trials. Crown Bioscience's HuPrime® Rectal cancer PDX models are well characterized for pathology, growth characteristics, and are also genetically/genomically annotated for gene expression, gene copy number, mutations, and fusions.

MODEL NUMBER CANCER TYPE CANCER SUBTYPE DESCRIPTION # per page
CR0004 Colorectal Cancer ADC Adenocarcinoma of colon, protruded type, moderately differentiated, invaded through intestinal wall to peripheral adipose tissue. Regional LN: paraintestinal LN (1/7). IHC results: HER-1(-), HER-2(-), p53( 50~75%+), p170(-), Ki-67(25~50%+), VEGF(+++), Top-IIa(<25%+), p16(<25%+). CLICK TO VIEW
CR0010 Colorectal Cancer ADC Adenocarcinoma of descending colon, carcinoma in situ, ulcerative type, well-moderately differentiated, tumor mass: 6cm x 4.5cm x 3.5cm. CLICK TO VIEW
CR0012 Colorectal Cancer ADC Adenocarcinoma of rectum, ulcerative type, carcinoma in situ, moderately differentiated, tumor mass: 6cm x 5.5cm x 1.5cm. CLICK TO VIEW
CR0024 Colorectal Cancer ADC Adenocarcinoma, moderately differentiated. CLICK TO VIEW
CR0028 Colorectal Cancer ADC Adenocarcinoma of ascending colon with part of mucinous adenocarcinoma, carcinoma in situ, ulcerative type, moderately differentiated, tumor mass: 7cm x 4.5cm x 2cm. CLICK TO VIEW
CR0029 Colorectal Cancer ADC Carcinoid, protruded type. CLICK TO VIEW
CR0047 Colorectal Cancer ADC Moderately to poorly differentiated adenocarcinoma CLICK TO VIEW
CR0126 Colorectal Cancer Mucinous adenocarcinoma Adenocarcinoma of the rectum with mucinous adenocarcinoma, moderately differentiated, ulcerative type, infiltrating into serosa, tumor mass: 5cm x 4cm x 1.5cm. No malignant cells adjacent to both stump. Regional LN: mesenteric LN (0/4). CLICK TO VIEW
CR0133 Colorectal Cancer ADC Moderately differentiated adenocarcinoma CLICK TO VIEW
CR0146 Colorectal Cancer ADC Adenocarcinoma with mucinous carcinoma, moderately-poorly differentiated, ulcerative type, infiltrating into serosa, tumor mass: 5cm x 4cm x 1cm. No malignant cells adjacent to both stump. Regional LN: mesenteric LN (0/5). CLICK TO VIEW
CR0150 Colorectal Cancer ADC Adenocarcinoma of cecum, moderately-poorly differentiated, ulcerative type, infiltrating into serosa, tumor mass: 5cm x 5cm x 1cm. No malignant cells adjacent to both stump. Regional LN: mesenteric LN (3/6). CLICK TO VIEW
CR0170 Colorectal Cancer ADC Adenocarcinoma of rectum, ulcerative type, moderately-poorly differentiated, infiltrating into deep muscular layer, tumor mass: 4cm x 3cm x 1cm. No malignant cells adjacent to both stump. Regional LN: mesenteric LN (0/2). CLICK TO VIEW
CR0193 Colorectal Cancer ADC Adenocarcinoma of colon, moderately differentiated, ulcerative type, infiltrating into serosa, tumor mass: 6.5cm x 4.5cm x 1.5cm. No malignant cells adjacent to both stump. Regional LN: mesenteric LN (0/9). CLICK TO VIEW
CR0196 Colorectal Cancer ADC Adenocarcinoma of the rectum, moderately differentiated, ulcerative type, infiltrating into serosa, tumor mass: 3.5cm x 3cm x 0.8cm. No malignant cells adjacent to both stump. Regional LN: mesenteric LN (8/10). CLICK TO VIEW
CR0205 Colorectal Cancer ADC 1.Adenocarcinoma of transverse colon, moderately-poorly differentiated, infiltrative type, invaded serosa, tumor mass: 8cm x 7cm x 1.5cm. No malignant cells adjacent to both stump. Regional LN: mesenteric LN(1/7). 2.Adenocarcinoma of duodenal papilla, moderately-poorly differentiated, invaded submucosa, tumor mass: 2.4cm x 1.2cm x 1cm. No malignant cells adjacent to both stump and pancreatic stump. Regional LN: parahepatic artery LN (0/2), LN surround common hepatic duct (0/3), greater curvature LN (0/2), parapyloric LN (0/8), parapancreatic LN (0/1). CLICK TO VIEW
CR0231 Colorectal Cancer ADC Moderately differentiated adenocarcinoma with part of mucinous adenocarcinoma CLICK TO VIEW
CR0245 Colorectal Cancer ADC, Mucinous Mucinous adenocarcinoma CLICK TO VIEW
CR0455 Colorectal Cancer ADC Adenocarcinoma of colon, poorly differentiated. CLICK TO VIEW
CR0460 Colorectal Cancer ADC Metastatic adenocarcinoma in liver. Chronic cholecystitis. Regional LN: LN of external gallbladder wall (2/2). CLICK TO VIEW
CR0560 Colorectal Cancer ADC Moderately to poorly differentiated adenocarcinoma CLICK TO VIEW

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