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Gastric Cancer PDX Models

With many new agents under development, including targeted therapies for gastric cancer, there is a need for predictive research models such as patient-derived xenografts (PDX) for preclinical evaluation. PDX models are proven to be highly predictive models for preclinical drug assessment. The Crown Bioscience collection contains over 100 well characterized gastric cancer PDX models, including EGFR amplified models and cachexic models. More

PDX offer the most translational preclinical model for efficacy screening in cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, PDX models reflect the heterogeneity and diversity of the human patient population. PDX give you an accurate, predictive model of how your treatment will perform, well before entering into expensive clinical trials. Crown Bioscience's HuPrime® PDX models are well characterized for pathology, growth characteristics, and are also genetically/genomically annotated for gene expression, gene copy number, mutations, and fusions.

MODEL NUMBER CANCER TYPE CANCER SUBTYPE DESCRIPTION # per page
GA0006 Gastric Cancer ADC Adenocarcinoma of gastric cardia of lesser curvature side, ulcerative type, carcinoma in situ, moderately-poorly differentiated, tumor mass: 6.5cm x 5cm x 2.5cm. CLICK TO VIEW
GA0019 Gastric Cancer ADC Adenocarcinoma of gastic cardia, infiltrative ulcerative type, moderately differentiated, tumor mass: 5cm x 4.5cm x 2.5cm, infiltrating into adipose tissue external serosa and nerve plexus in gastric wall. Malignant cells were observed in lesser curvature LN and cardial LN. CLICK TO VIEW
GA0022 Gastric Cancer ADC Adenocarcinoma of gastic cardia, ulcerative type, moderately-poorly differentiated, tumor mass: 5cm x 4cm x 2.5cm, infiltrating gastric wall to serosa. No visible malignant cells adjacent to both stump. Regional LN: left gastric LN (5/9), LN of inferior parapulmonary vein (0/6). CLICK TO VIEW
GA0023 Gastric Cancer ADC Adenocarcinoma, ulcerative type, poorly differenciated. CLICK TO VIEW
GA0025 Gastric Cancer Signet-ring cell carcinoma Signet-ring cell carcinoma of gastric greater curvature, parts are mucinous adenocarcinoma, protruded type, tumor mass: 3.5cm x 3.5cm x 2cm, infiltrating into gastric wall. Regional LN: LN surround celiac trunk (1/1). IHC results: HER-1(-), HER-2(-), p53(-), p170(-), Ki-67(+ 25~50%), VEGF(+), TopIIa(+<25%), p16(-). CLICK TO VIEW
GA0031 Gastric Cancer ADC Adenocarcinoma of stomach, ulcerative type, moderately-poorly differentiated, tumor mass: 6cm x 4cm x 1cm, infiltrating into serosa. No visible malignant cells adjacent to both stump. Regional LN: LN of lesser curvature (2/5), LN of greater curvature (0/2). CLICK TO VIEW
GA0033 Gastric Cancer ADC Adenocarcinoma of gastric cardia, ulcerative type, poorly differentiated, tumor mass: 9cm x 6cm x 1.5cm, infiltrating into serosa, and accompanied with necrosis and a few lymphocytes deposition. No visible malignant cells adjacent to both stump. Regional LN: cardial LN (0/5), left gastric LN (0/7). CLICK TO VIEW
GA0037 Gastric Cancer ADC Adenocarcinoma of gastric cardia, ulcerative type,poorly differentiated, tumor mass: 4cm x 4cm x 2.5cm, infiltrating into serosa. No visible malignant cells adjacent to both stump. Regional LN: LN of lesser curvature (0/9). CLICK TO VIEW
GA0044 Gastric Cancer ADC Metastatic adenocarcinoma derived from liver, moderately-poorly differenciated. The patient had been done gastric cancer surgery 2 years ago. CLICK TO VIEW
GA0046 Gastric Cancer ADC Adenocarcinoma derived from juncture of stomach and esophagus in lesser gastric curvature, protrude, ulcerative type, poorly differentiated, tumor mass: 6cm x 5cm x 1.5cm. Malignant cells infiltrating into gastric wall and esophagus. Regional LN: LN of lesser curvature (3/14). IHC results: HER-1(+), HER-2(-), p53(+ 25~50%), p170(-),Ki-67(+, 25-50%), VEGF(++), Top-IIa(+ about 10%), p16(-). CLICK TO VIEW
GA0055 Gastric Cancer ADC Clear cell adenocarcinoma of anterior wall of gastric antrum, ulcerative type, moderately differentiated. Regional LN: LN of lesser curvature (2/6), LN of greater curvature (2/6), LN of the eighth group (1/1). IHC results: HER-1(-), HER-2(+), p53(+ 25~50%), p170(focus +), Ki-67(+<10%), VEGF(++), Top-IIa(+<1%), p16(++). CLICK TO VIEW
GA0060 Gastric Cancer ADC Adenocarcinoma of gastric antrum, ulcerative type, moderately-poorly differentiated, tumor mass: 4cm x 6cm x 2cm, invaded adipose tissue external serosa, no visible malignant cells adjacent to both stump. Regional LN: LN of greater curvature (7/7), LN of lesser curvature (6/6). CLICK TO VIEW
GA0074 Gastric Cancer ADC Adenocarcinoma of gastric cardia, ulcerative type, poorly differentiated, tumor mass: 5cm x 4cm x 0.8cm, invading deep muscular layer and massive gastric wall. No malignant cells adjacent to both stump. Regional LN: LN of lesser curvature (1/3), cardial LN (0/5). CLICK TO VIEW
GA0075 Gastric Cancer ADC Adenocarcinoma of cardia and fundus of stomach, infiltrative ulcerative type, moderately-poorly differentiated, tumor mass: 6.5cm x 5cm x 1.5cm, infiltrating into serosa. No malignant cells adjacent to both stump. Regional LN: LN of lesser curvature(1/6), cardial LN(0/4), LN of greater curvature (0/4), LN of para-inferior pulmonary vein (0/3). CLICK TO VIEW
GA0080 Gastric Cancer ADC 1. Adenocarcinoma of gastric cardia, invasive type, moderately-poorly differentiated, tumor mass: 8cm x 6cm x 1.5cm, infiltrating into serosa. No visible malignant cells adjacent to both stump. Regional LN: cardial LN (1/5), left gastric LN (2/2). 2. Hepatitis, type B CLICK TO VIEW
GA0087 Gastric Cancer NEC, carcinoid Carcinoid of gastric cardia, ulcerative type, tumor mass: 7cm x 5.5cm x 1.5cm, invading into serosa, no malignant cells adjacent to both stump and omentum majus. Regional LN: LN of lesser curvature (3/4), inferior esophageal LN (0/1). IHC results: Syn(-), CgA(+), NSE(-). CLICK TO VIEW
GA0091 Gastric Cancer NEC, carcinoid Carcinoid of gastric cardia, ulcerative type, tumor mass: 7cm x 5.5cm x 1.5cm, invading into serosa, no malignant cells adjacent to both stump and omentum majus. Regional LN: LN of lesser curvature (3/4), inferior esophageal LN (0/1). IHC results: Syn(-), CgA(+), NSE(-). CLICK TO VIEW
GA0095 Gastric Cancer ADC Adenocarcinoma of gastic cardia, ulcerative type, poorly differentiated, tumor mass: 6cm x 5cm x 2.5cm, invaded nerve plexus of gastric wall and adipose tissue external serosa. No visible malignant cells adjacent to superior stump. Severe acinar hyperplasia in inferior stump. Regional LN: lymphatic fusion were observed in lesser curvature and cardia. Metastatic tumor cell presented in the LN. CLICK TO VIEW
GA0098 Gastric Cancer ADC Adenocarcinoma of gastric cardia, invasive, ulcerative type, moderately differentiated, tumor mass: 5cm x 4.5cm x 2cm, infiltrating into serosa and squamous epithelium of inferior esophagus. No visible malignant cells adjacent to both stump. Regional LN: paraesophageal LN (0/1), cardial LN (0/5). Lymphatic fusion were observed in lesser curvature. Metastatic tumor cell presented in the LN. CLICK TO VIEW
GA0103 Gastric Cancer ADC moderately-poorly differentiated adenocarcinoma of gastric cardia (ulcerative) CLICK TO VIEW
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