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GIST PDX Models

While the genetic reasons behind imatinib acquired resistance in gastrointestinal stromal tumors (GIST) are well known, the development of new agents to overcome this resistance has been limited. This is due to a lack of preclinical models which fully recapitulate the complex interplay of KIT primary and secondary mutations seen in the clinical population. Crown Bioscience provides the world’s most comprehensive panel of GIST patient-derived xenograft (PDX) models, ideal for the preclinical evaluation of novel therapies to circumvent imatinib resistance. More

PDX offer the most translational preclinical model for efficacy screening in cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, PDX models reflect the heterogeneity and diversity of the human patient population. PDX give you an accurate, predictive model of how your treatment will perform, well before entering into expensive clinical trials. Crown Bioscience's HuPrime® PDX models are well characterized for pathology, growth characteristics, and are also genetically/genomically annotated for gene expression, gene copy number, mutations, and fusions.

MODEL NUMBER CANCER TYPE CANCER SUBTYPE DESCRIPTION # per page
GS11327 GIST GIST Gastrintestinal StromalSarcoma. Pathol comment: c/w refering diagnosis. Approximately 90% of the tissue involved by tumor in sections examined. Tumor cells present in cytospin prep. CLICK TO VIEW
GS11328 GIST GIST Gastrointestinal Stromal Tumor. GIST. Pathol comment: c/w diagnosis. Approximately 90% of the tissue involved by tumor in sections examined. Tumor cells present in cytospin prep. CLICK TO VIEW
GS11329 GIST GIST Gastrointestinal Stromal Tumor. Stromal tumor HG. Pathol comment: Approximately 80% of the tissue involved by tumor in sections examined. Tumor cells present in cytospin prep. CLICK TO VIEW
GS11331 GIST GIST Gastrointestinal Stromal Tumor. Pathol comment: c/w refering diagnosis. Malignant tumor cells present in sections examined and cytospin prep. CLICK TO VIEW
GS11339 GIST GIST Gastrointestinal Stromal Tumor. Pathol comment: c/w refering diagnosis. Entire tissue involved by malignant tumor in sections examined. Malignant tumor cells present in cytospin prep. CLICK TO VIEW
GS11342 GIST GIST Gastrointestinal Stromal Tumor. Pathol comment: c/w refering diagnosis. Entire tissue involved by malignant tumor in sections examined. Malignant tumor cells present in cytospin prep. CLICK TO VIEW
GS11351 GIST GIST Gastrointestinal stromal tumor. Pathol comment: c/w diagnosis. Approximately 100% of the tissue involved by tumor in sections examined. Approximately 80% malignant tumor cells present in cytospin prep. CLICK TO VIEW
GS11353 GIST GIST Gastrointestinal stromal tumor. Pathol comment: Approximately 100% of the tissue involved by tumor in sections examined. Focal tumor necrosis. Approximately 80% malignant tumor cells present in cytospin prep. CLICK TO VIEW
GS11354 GIST GIST Gastrointestinal stromal tumor. Pathol comment: c/w diagnosis. Approximately 100% of the tissue involved by tumor in sections examined. Approximately 80% malignant tumor cells present in cytospin prep. CLICK TO VIEW
GS11360 GIST GIST Malignant GIST CLICK TO VIEW
GS5106 GIST GIST (cKIT mut) gastrointestinal stromal tumor. Pathol comment: c/w diagnosis. approximately 90% of the tissue involved by malignant tumor in sections examined. malignant tumor cells present in cytospin prep. CLICK TO VIEW
GS5107 GIST GIST (cKIT mut) gastrointestinal stromal tumor. Pathol comment: c/w diagnosis. approximately 90% of the tissue involved by malignant tumor in sections examined. malignant tumor cells present in cytospin prep. CLICK TO VIEW
GS5108 GIST GIST (cKIT mut) gastrointestinal stromal tumormultiple metastatic gastrointestinal stromal sarcoma. Pathol comment: c/w diagnosis. approximately 80% of the tissue involved by malignant tumor in sections examined. malignant tumor cells present in cytospin prep. CLICK TO VIEW

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