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Kidney Cancer PDX Models

Suitable preclinical models such as patient-derived xenografts (PDX) are needed to evaluate drugs specifically targeting kidney cancer. PDX models are known to be the most predictive preclinical model and provide an accurate approach to evaluating an agent’s efficacy prior to entering the clinic. The Crown Bioscience kidney cancer PDX collection consists of several models, including models from both North American and Asian descent. More

PDX offer the most translational preclinical model for efficacy screening in cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, PDX models reflect the heterogeneity and diversity of the human patient population. PDX give you an accurate, predictive model of how your treatment will perform, well before entering into expensive clinical trials. Crown Bioscience's HuPrime® PDX models are well characterized for pathology, growth characteristics, and are also genetically/genomically annotated for gene expression, gene copy number, mutations, and fusions.

MODEL NUMBER CANCER TYPE CANCER SUBTYPE DESCRIPTION # per page
KI0326 Kidney Cancer CCRCC Clear cell carcinoma of left kidney CLICK TO VIEW
KI0551 Kidney Cancer TCC Transitional cell carcinoma CLICK TO VIEW
KI10101 Kidney Cancer NA NA for clinical diagnosis info. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 90% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
KI10102 Kidney Cancer NA oncocystic neoplasm. Pathol comment: APPROXIMATELY 60% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
KI10105 Kidney Cancer RCC Renal Carcinoma. Sarcomatoid renal cell carcinoma. CLICK TO VIEW
KI10106 Kidney Cancer RCC Renal Cell Carcinoma. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 70% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
KI10115 Kidney Cancer NA cystic nephroma / mixed epithelial and stromal tumor. Pathol comment: NO MALIGNANT CELLS PRESENT IN TISSUE SECTIONS EXAMINED AND CYTOSPIN PREPARATION. TISSUE SECTIONS SHOW A LESION CONSISTENT WITH A CYSTIC NEPHROMA/MIXED EPITHELIAL AND STROMAL TUMOR. CLICK TO VIEW
KI11409 Kidney Cancer NA Kidney Carcinoma. Pathol comment: APPROXIMATELY 90% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
KI1410 Kidney Cancer RCC Metastatic renal clear cell carcinoma to lung. Tumor is forms cribriform or nest structures and has an infiltrative growth pattern. Tumor cells show clear cytoplasm or acidophily cytoplasm with the nuclear atypia. Regional LN: the seventh group LN (1/5), the second group LN (0/5), the fourth group (0/3), the tenth group LN (0/2). CLICK TO VIEW
KI16031 Kidney Cancer NA Metastatic clear cell carconoma, C/W RENAL PRIMARY. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 90% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
KI2361 Kidney Cancer CCRCC NA CLICK TO VIEW
KI2367 Kidney Cancer RCC Clear cell renal cell carcinoma of right kidney CLICK TO VIEW
KI2368 Kidney Cancer RCC Metastatic clear cell renal cell carcinoma of kidney primary (from KI2367) in subcutaneous nodule. IHC results: CD10(+), EMA(+), CK8/18(-), Vimentin(+). CLICK TO VIEW
KI2389 Kidney Cancer CCRCC Left kidney: clear cell carcinoma, grade III, with necrosis. CLICK TO VIEW
KI2407 Kidney Cancer RCC Renal cell carcinoma, clear cell renal cell carcinoma with focal sarcomatoid component CLICK TO VIEW
KI2430 Kidney Cancer SCC N/A CLICK TO VIEW
KI2432 Kidney Cancer NA NA CLICK TO VIEW
KI2479 Kidney Cancer CCRCC N/A CLICK TO VIEW
KI2552 Kidney Cancer NA Lung Met from Renal Cell Carcinoma CLICK TO VIEW
KI9309 Kidney Cancer NA NA CLICK TO VIEW
KI9310 Kidney Cancer NA NA CLICK TO VIEW
KI9316 Kidney Cancer RCC NA CLICK TO VIEW

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