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Lymphoma PDX Models

Identifying robust preclinical models for lymphoma is essential for the development of new therapies targeting this disease. Patient-derived xenograft (PDX) models provide a predictive preclinical model with true representation of the human heterogeneity providing an accurate approach to predicting an agent’s efficacy prior to entering the clinic. The Crown Bioscience lymphoma PDX collection consists of many models, including both primary and metastatic models. More

PDX offer the most translational preclinical model for efficacy screening in cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, PDX models reflect the heterogeneity and diversity of the human patient population. PDX give you an accurate, predictive model of how your treatment will perform, well before entering into expensive clinical trials. Crown Bioscience’s HuPrime® PDX models are well characterized for pathology, growth characteristics, and are also genetically/genomically annotated for gene expression, gene copy number, mutations, and fusions.
MODEL NUMBER CANCER TYPE CANCER SUBTYPE DESCRIPTION # per page
LY0257 Lymphoma NHL (DLBCL, ABC, MYD88 L265P) Non-Hodgkin's lymphoma (large B cell). IHC results: CD20(+), CD45RO(-), CD3(-), CD15(-), CD79alpha(+), CD30(-), CK(-), CD56(-). CLICK TO VIEW
LY14019 Lymphoma NHL Non-Hodgkin's Lymphoma CLICK TO VIEW
LY2104 Lymphoma EBV transformed lymphoma N/A CLICK TO VIEW
LY2118 Lymphoma EBV transformed lymphoma Gastric cancer, tumor mass: 8cm x 7cm, inflammatory cells infiltrated through body and gastric antrum, Small tumor foci are remained, consistent with the changes after chemotherapy. Regional LN: right cardial LN (0/5), left cardial LN (0/7), LN of vasa brevia (0/2), left gastroepiploic vascular LN (0/2), right gastroepiploic vascular LN (0/1), inferior pyloric LN (0/1), LN of left gastric artery (0/3), LN of hepatic artery in ligamentum hepatoduodenale(0/1). IHC results: CD44(+), Cmet(weak +), EGFR(+), HER2(3+), Ki-67(+50-75%), MMP7(-), P170(-), P27(+50-75%), P53(+>75%), TOPOII(-). CLICK TO VIEW
LY2201 Lymphoma Lymphoma NA CLICK TO VIEW
LY2214 Lymphoma NHL (DLBCL, GCB) Non-Hodgkin lymphoma (large B cell). IHC results: CD3(-), CD45RO(-), CD20(+), CD79 a(+), Ki-67(80%), CD10(-),CD30(-), ALK(-), Bcl-6(-), MUM1(-). CLICK TO VIEW
LY2219 Lymphoma EBV transformed lymphoma gastric adenocarcinoma, signet ring cell carcinoma CLICK TO VIEW
LY2240 Lymphoma EBV transformed lymphoma gastric caner CLICK TO VIEW
LY2264 Lymphoma NHL (DLBCL, ABC, MYD88 L265P) Non-Hodgkin's lymphoma (diffuse large B cell lymphoma). IHC results: CD3(-), CK(-), CD20(+), Vim(+/-), CD79 a(+/-), CD45RO(-), Ki67(80%), CD30(-), HMB45(-), Mart-1(-), Pax-5(+), Bc1-6(+), EMA(-), CK7(-), P63(-), ALK(-), CD10(-). CLICK TO VIEW
LY2266 Lymphoma NHL (B cell, ABC/GCB) Non-Hodgkin's lymphoma (B cell lymphoma with plasma cell differentiation). IHC results: CK(-), CD20(+), CD3(-), CD79 a(+), Ki-67(40%), CD5(-), CyclinD1(-), CD138(+/-), CD56(-), CD10(-), Bc1-6(-), Pax-5(+), MUM1(+/-), CD45RO(-). CLICK TO VIEW
LY2298 Lymphoma B cell lymphoma (ABC/GCB, MYD88 L265P) B cell lymphoma of right forehead. IHC results: CD20(++), CD79a(+), Ki-67(+ 80%), CD56(-), CD3(-), CD45RO(-), NSE(-), GFAP(-), Syn(-), S-100(-). CLICK TO VIEW
LY2301 Lymphoma NHL (DLBCL, ABC) Reactive hyperplasia of lymph node CLICK TO VIEW
LY2310 Lymphoma B cell lymphoma N/A CLICK TO VIEW
LY2318 Lymphoma NHL (DLBCL, GCB) NA for clinical diagnosis info. CLICK TO VIEW
LY2345 Lymphoma NHL (DLBCL, ABC/GCB) Non Hodgkin lymphoma (consider large B cell lymphoma). IHC result: CD3(-), CD45Ro(-), CD20(+), CD79a(+), Pax-5(+), CD5(+/-), CD10(+), BCL-6(-), CyclinD1(-), MUM1(+). CLICK TO VIEW
LY3071 Lymphoma EBV transformed lymphoma Lung: Bronchioloalveolar carcinoma of lung, peripheral type. CLICK TO VIEW
LY3148 Lymphoma Burkitt lymphoma Burkitt lymphoma of parapharynx and paracranium. CLICK TO VIEW
LY3463 Lymphoma B cell lymphoma NA CLICK TO VIEW
LY3604 Lymphoma NHL (DLBCL, ABC/GCB) Diffuse large B cell lymphoma CLICK TO VIEW
LY3654 Lymphoma Follicular lymphoma Posterior peritoneum: follicular lymphoma CLICK TO VIEW
LY3786 Lymphoma NA Left axillary lymph node: malignant lymphoma CLICK TO VIEW
LY6696 Lymphoma NA NA for clinical diagnosis info. CLICK TO VIEW
LY6701 Lymphoma DLBCL, GCB Right lobe of liver: Non-Hodgkin lymphoma, diffuse large B cell lymphoma CLICK TO VIEW
LY6931 Lymphoma ALCL, anaplastic large cell lymphoma ALCL, anaplastic large cell lymphoma CLICK TO VIEW
LY6933 Lymphoma NHL (DLBCL, ABC/GCB) Diffuse large B cell lymphoma, derived from activated b lymphocyte CLICK TO VIEW
LY6934 Lymphoma NHL (DLBCL, ABC/GCB) Diffuse large B cell lymphoma CLICK TO VIEW
LY6938 Lymphoma Lymphoma NA CLICK TO VIEW

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