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Melanoma PDX Models

Melanoma is the least common, yet most deadly form of skin cancer and requires predictive research models such as patient-derived xenografts (PDX) for preclinical evaluation of new cancer treatments. PDX models maintain a true representation of human heterogeneity and provide the most accurate approach to predicting an agent’s efficacy prior to entering the clinic. The Crown Bioscience melanoma PDX collection contains over 200 models including metastatic and primary disease models with clinically relevant mutations e.g. BRAF(V600E). More

PDX offer the most translational preclinical model for efficacy screening in cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, PDX models reflect the heterogeneity and diversity of the human patient population. PDX give you an accurate, predictive model of how your treatment will perform, well before entering into expensive clinical trials. Crown Bioscience's HuPrime® PDX models are well characterized for pathology, growth characteristics, and are also genetically/genomically annotated for gene expression, gene copy number, mutations, and fusions.

MODEL NUMBER CANCER TYPE CANCER SUBTYPE DESCRIPTION # per page
ME1154 Melanoma NA Metastatic malignant melanoma of left inguinal LN CLICK TO VIEW
ME11971 Melanoma NA Malignant melanoma CLICK TO VIEW
ME11972 Melanoma NA Adeno CLICK TO VIEW
ME11982 Melanoma NA Malignant melanoma CLICK TO VIEW
ME11985 Melanoma NA Malignant melanoma CLICK TO VIEW
ME11987 Melanoma NA Malignant melanoma CLICK TO VIEW
ME11994 Melanoma NA Malignant melanoma CLICK TO VIEW
ME11995 Melanoma NA Mets melanoma CLICK TO VIEW
ME12000 Melanoma NA Malignant melanoma CLICK TO VIEW
ME12002 Melanoma NA Malignant melanoma CLICK TO VIEW
ME12003 Melanoma NA Metastatic melanoma CLICK TO VIEW
ME12006 Melanoma NA Malignant melanoma CLICK TO VIEW
ME12007 Melanoma NA Recurrent malignant melanoma CLICK TO VIEW
ME12009 Melanoma NA Malignant melanoma CLICK TO VIEW
ME12010 Melanoma NA Melanoma, metastatic CLICK TO VIEW
ME12011 Melanoma NA Malignant melanoma, metastatic CLICK TO VIEW
ME12016 Melanoma NA Malignant melanoma CLICK TO VIEW
ME12019 Melanoma NA Malignant melanoma. Pathol comment: THE TISSUE CONTAINS 90% TUMOR C/W REFERRING DIAGNOSIS. 10% NECROSIS. TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
ME12024 Melanoma NA Metastatic Melanoma. Pathol comment: THE TISSUE CONTAINS 90% TUMOR C/W REFERRING DIAGNOSIS. TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
ME12026 Melanoma NA Infiltrating malignant neoplasm, C/W MELANOMA. Pathol commnet: THE TISSUE CONTAINS 80% TUMOR C/W REFERRING DIAGNOSIS. 50% NECROSIS. TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW

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