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Metastatic Carcinoma PDX Models

Suitable preclinical models such as patient-derived xenografts (PDX) are needed to evaluate drugs specifically targeting metastatic carcinoma. PDX models are known to be the most predictive preclinical model for evaluating an agent’s efficacy prior to entering the clinic. More

PDX offer the most translational preclinical model for efficacy screening in cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, PDX models reflect the heterogeneity and diversity of the human patient population. PDX give you an accurate, predictive model of how your treatment will perform, well before entering into expensive clinical trials. Crown Bioscience’s HuPrime® PDX models are well characterized for pathology, growth characteristics, and are also genetically/genomically annotated for gene expression, gene copy number, mutations, and fusions.

MODEL NUMBER CANCER TYPE CANCER SUBTYPE DESCRIPTION # per page
MC0665 Metastatic Carcinoma SCC Squamous cell carcinoma of adipose connective tissue from right groin, moderately differentiated. No malignant cells adjacent to incisal margin and basement. CLICK TO VIEW
MC1392 Metastatic Carcinoma NA Invasive squamous cell carcinoma from pelvic cavity wall, right fossa iliaca and ilium. CLICK TO VIEW
MC1454 Metastatic Carcinoma NA Metastatic squamous cell carcinoma to right chest wall CLICK TO VIEW
MC2296 Metastatic Carcinoma NA Malignant tumor of left trigonum (consider neuroendocrine carcinoma metastatic to brain), suggest to do clinical lung examination. CLICK TO VIEW
MC3050 Metastatic Carcinoma NA Metastatic adenocarcinoma to greater omentum. CLICK TO VIEW
MC3084 Metastatic Carcinoma NA Metastatic adenocarcinoma to left neck lymph node. CLICK TO VIEW
MC3128 Metastatic Carcinoma SCC Metastatic squamous cell carcinoma to right neck LN. CLICK TO VIEW
MC3160 Metastatic Carcinoma SCC Right neck lymph node: consider metastatic poorly differentiated carcinoma on the basis of IHC results, and squamous cell carcinoma is dominated CLICK TO VIEW
MC3161 Metastatic Carcinoma NA NA CLICK TO VIEW
MC3359 Metastatic Carcinoma Adenocarcinoma Right gluteal region: invasive adenocarcinoma, metastatic adenocarcinoma can not be ruled out. CLICK TO VIEW
MC3405 Metastatic Carcinoma ADC Left ovary: metastatic adenocarcinoma CLICK TO VIEW
MC3464 Metastatic Carcinoma SCC Right neck: metastatic squamous cell carcinoma in lymph nodes (14/21), consider metastatic squamous cell carcinoma, while high grade mucoepidermoid carcinoma need to be excluded. CLICK TO VIEW
MC3603 Metastatic Carcinoma SCC Metastatic squamous cell carcinoma in lymph nodes (2/28) CLICK TO VIEW
MC3624 Metastatic Carcinoma ADC Right neck: based on medical history, consider tumor is metastatic poorly differentiated squamous cell carcinoma CLICK TO VIEW
MC3685 Metastatic Carcinoma ADC Left supraclavicular lymph nodes: based on IHC results, consider tumor is metastatic poorly differentiated carcinoma CLICK TO VIEW
MC6624 Metastatic Carcinoma NA Left side of liver and stomach: poorly differentiated squamous cell carcinoma with massive necrosis, infiltrating to gastric submucosa. Five of nine lymph nodes involved by metastatic carcinoma (5/9). IHC results: Hepa(-), AFP(-), CD34(blood vessel +), CK7(-), CK19(+++), HSP-70(++), GS(small +), GPC-3(-), KI67(50%+), HCK(+++), P63(+), CK8(+++), SYN(-), CHG(-), CD56(-), MUC-1(-), MUC-2(-), MUC-4(-), MUC-5(-), MUC-6(-). CLICK TO VIEW

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