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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Tissue

Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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KRAS

Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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EGFR

Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Bioinformatics

Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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CRISPR/Cas9

Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Genomics

Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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Biomarker Discovery

De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Laboratory Services

Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.

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Pharmacology & Bioanalytical Services

Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Screens

Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Toxicology

Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Our Company

Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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Our Purpose

Learn more about the impact we make through our scientific talent, high-quality standards, and innovation.

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Our Responsibility

We build a sustainable future by supporting employee growth, fostering leadership, and exceeding customer needs. Our values focus on innovation, social responsibility, and community well-being.

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Meet Our Leadership Team

We build a sustainable future by fostering leadership, employee growth, and exceeding customer needs with innovation and social responsibility.

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Scientific Advisory Board

Our Scientific Advisory Board of experts shapes our strategy and ensures top scientific standards in research and development.

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Mixed Mullerian Cancer PDX Models

Suitable preclinical models such as patient-derived xenografts (PDX) are needed to evaluate drugs targeting mixed mullerian cancer. PDX models are known to be the most predictive preclinical model and provide an accurate approach to evaluating an agent’s efficacy prior to entering the clinic. More

PDX offer the most translational preclinical model for efficacy screening in cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, PDX models reflect the heterogeneity and diversity of the human patient population. PDX give you an accurate, predictive model of how your treatment will perform, well before entering into expensive clinical trials. Crown Bioscience’s HuPrime® PDX models are well characterized for pathology, growth characteristics, and are also genetically/genomically annotated for gene expression, gene copy number, mutations, and fusions.

MODEL NUMBER CANCER TYPE CANCER SUBTYPE DESCRIPTION # per page
MU12499 Mixed Mullerian Cancer N/A N/A CLICK TO VIEW
MU12506 Mixed Mullerian Cancer NA Mixed muellerian cell. c/w Carcinosarcoma. Pathol comment: C/W REFERRING DIAGNOSIS. ENTIRE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
MU12527 Mixed Mullerian Cancer NA Mixed Muellerian Cell. Pathol comment: APPROXIMATELY 60% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
MU12533 Mixed Mullerian Cancer NEC Mixed muellerian cell. c/w Carcinosarcoma. Pathol comment: C/W REFERRING DIAGNOSIS. MALIGNANT TUMOR CELLS PRESENT IN CELL BLOCK SECTION AND CYTOSPIN PREP. CLICK TO VIEW
MU12540 Mixed Mullerian Cancer SCLC Mixed Muellerian Cell. MALIGNANT MIXED MULLERIAN TUMOR. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 50% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
MU12541 Mixed Mullerian Cancer NA Mixed Muellerian Cell. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 90% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
MU12554 Mixed Mullerian Cancer NA Mixed Muellerian Cell. MALIGNANT MIXED MESODERMAL TUMOR, HETEROLOGOUS TYPE. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 90% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
MU12555 Mixed Mullerian Cancer N/A N/A CLICK TO VIEW
MU12561 Mixed Mullerian Cancer NA Mixed Muellerian of Uterus. Pathol comment: C/W REFERRING DIAGNOSIS. MALIGNANT TUMOR CELLS PRESENT IN CELL BLOCK SECTION AND CYTOSPIN PREP. CLICK TO VIEW
MU12575 Mixed Mullerian Cancer SCLC Mixed Muellerian Cell. MALIGNANT MIXED MUELLERIAN TUMOR. Pathol comment: C/W REFERRING DIAGNOSIS. ENTIRE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
MU12582 Mixed Mullerian Cancer NA Mixed Muellerian Cell. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 60% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
MU12603 Mixed Mullerian Cancer NA Mixed Muellerian Cell. CARCINOMA, PD WITH SEROUS PAPILLARY & CLEAR CELL FEATURES. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 50% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
MU12652 Mixed Mullerian Cancer NA Mixed Muellerian Cell. CARCINOSARCOMA. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 90% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
MU12659 Mixed Mullerian Cancer Sarcoma Malignant Mixed Muellerian Cell. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 80% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
MU12666 Mixed Mullerian Cancer NA MALIGNANT MIXED MULLERIAN TUMOR OF THE UTERUS. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 60% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
MU12729 Mixed Mullerian Cancer Sarcoma Mixed Muellerian Cell. CARCINOSARCOMA. Pathol comment: APPROXIMATELY 90% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. FOCAL TUMOR NECROSIS. APPROXIMATELY 70% MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREPARATION. CLICK TO VIEW
MU12764 Mixed Mullerian Cancer NA Carcinosarcoma. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 100% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. APPROXIMATELY 80% MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREPARATION. CLICK TO VIEW
MU12778 Mixed Mullerian Cancer NA Mixed mullerian tumor. METASTATIC CARCINOSARCOMA, HIGH GRADE. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 100% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. ONLY A CARCINOMATOUS COMPONENT IS SEEN. APPROXIMATELY 80% MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREPARATION. CLICK TO VIEW
MU12813 Mixed Mullerian Cancer NA Mixed Muellerian Cell. CARCINOSARCOMA. Pathol comment: CLICK TO VIEW

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