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Ovarian Cancer PDX Models

The Crown Bioscience ovarian cancer patient-derived xenograft (PDX) collection consists of several models including a treatment resistant model. PDX models present a true representation of the human heterogeneity of gynecologic malignancies and provide the most accurate approach to predicting an agents efficacy prior to entering the clinic. More

PDX offer the most translational preclinical model for efficacy screening in cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, PDX models reflect the heterogeneity and diversity of the human patient population. PDX give you an accurate, predictive model of how your treatment will perform, well before entering into expensive clinical trials. Crown Bioscience’s HuPrime® PDX models are well characterized for pathology, growth characteristics, and are also genetically/genomically annotated for gene expression, gene copy number, mutations, and fusions.

MODEL NUMBER CANCER TYPE CANCER SUBTYPE DESCRIPTION # per page
OV0243 Ovarian Cancer Papillary adenocarcinoma Pathology QC: Papillary adenocarcinoma (P4, P7). CLICK TO VIEW
OV0250 Ovarian Cancer Endometrioid adenocarcinoma Mixed adenocarcinoma of ovary. Endometrioid adenocarcinoma, grade III, invaded the uterine wall. CLICK TO VIEW
OV0273 Ovarian Cancer NA Embryonal carcinoma of right ovary. No malignant cells adjacent to right oviduct. IHC results: CD56(+/-),Syn(+/-),CK(+/-),CD117(+/-),AR(-), PLAP(-), CA1259(-). CLICK TO VIEW
OV0276 Ovarian Cancer ADC Mucinous adenocarcinoma of ovary (could not exclude Krukenberg's tumor). No malignant cells adjacent to oviduct and perimetrium. Regional LN: LN of abdominal aorta (2/2). CLICK TO VIEW
OV0589 Ovarian Cancer NA NA for clinical diagnosis info. Pathology QC: Papillary adenocarcinoma (Pa, P1) CLICK TO VIEW
OV1200 Ovarian Cancer ADC Adenocarcinoma of both ovary and oviduct, poorly to moderately differentiated. CLICK TO VIEW
OV1272 Ovarian Cancer cystadenoma Mucinous cystadenoma of bilateral ovary. The tumor of bilateral adnexa uteri forms irregular glandular structures and has an infiltrative growth pattern. IHC results: PR(-), ER(-), CK7(+), CK20(-), Villin(+). CLICK TO VIEW
OV1286 Ovarian Cancer ADC Adenocarcinoma of right ovary. CLICK TO VIEW
OV1327 Ovarian Cancer Serous papillary cystadenocarcinoma Papillary serous cystadenocarcinoma of right ovary. The tumor forms irregualar papillary glandular structures and has an infiltrative growth pattern. Columnar epithelial cells may be seen. The neoplastic cells invasive pelvic cavity and greater omentum. CLICK TO VIEW
OV1365 Ovarian Cancer ADC Mixed epithelial malignant tumor of left ovary, include serous adenocarcinoma, clear cell carcinoma and hepatoid adenocarcinoma. Tumor forms nest and papillary structures and has an infiltrative growth pattern. Regional LN: left obturator LN (1/6), left inguinal LN (0/3), left internal and external iliac (0/4), left common iliac LN (0/7), right common iliac LN (0/2), right internal and external iliac LN (0/5), right inguinal LN (0/4), right obturator LN (0/4). CLICK TO VIEW
OV1385 Ovarian Cancer Cystadenoma 1. Mucous cystadenocarcinoma of bilateral ovary. The tumor forms adenoid tubular and nest structures and has an infiltrative growth pattern. Malignant cells are viewed within bilateral fimbriae oviduct.Regional LN: LN of greater omentum (0/3). 2. Chronic appendicitis CLICK TO VIEW
OV13950 Ovarian Cancer NA NA for clinical diagnosis info. CLICK TO VIEW
OV1396 Ovarian Cancer NA Poorly differentiated serous papillary carcinoma of bilateral oviduct and involving bilateral ovary. The tumor forms irregular papillary, solid forms and has an infiltrative growth pattern. Regional LN: LN of right abdominal aorta (3/4), left obturator LN (1/3), right obturator LN (2/3), left groin LN (2/2), left interna and external iliac LN (1/1), right common iliac (1/3), right gorin (0/3), left common iliac LN (0/4). CLICK TO VIEW
OV14654 Ovarian Cancer N/A N/A CLICK TO VIEW
OV14972 Ovarian Cancer NA Ovarian Carcinoma. Pathol comment: C/W REFERRING DIAGNOSIS. MICROSCOPIC FOCUS OF MALIGNANT TUMOR PRESENT IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
OV15013 Ovarian Cancer NA Metastatic serous papillary carconoma, PD. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 80% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
OV15398 Ovarian Cancer NA Ovarian Carcinoma. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 100% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
OV15612 Ovarian Cancer NA Ovarian Carcinoma. Pathol comment: C/W DIAGNOSIS. APPROXIMATELY 100% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. FOCAL TUMOR NECROSIS. APPROXIMATELY 70% MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREPARATION. CLICK TO VIEW
OV15631 Ovarian Cancer NA Ovarian Carcinoma. Pathol comment: MALIGNANT TUMOR CELLS PRESENT IN CELL BLOCK. APPROXIMATELY 90% MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREPARATION. C/W DIAGNOSIS. CLICK TO VIEW
OV1579 Ovarian Cancer NA Left ovary: moderately-poorly differentiated adenocarcinoma. CLICK TO VIEW

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