The huPD-1/CTLA-4 model is a valuable tool for studying immune checkpoint pathways and their modulation in cancer research. This model features the introduction of human PD-1 and CTLA-4 genes into the C57BL/6 mouse strain, enabling the investigation of their expression and function in an in vivo setting.
Key Features:
Cancer Type: N/A
Type: Double Knock-In
Target: Human PD-1/CTLA-4
Mouse Strain: C57BL/6
Validation of Human Target Expression
The huPD-1/CTLA-4 model is designed to mimic the expression and interaction of human PD-1 and CTLA-4 immune checkpoint molecules. By introducing these human genes into the C57BL/6 mouse strain, researchers can study the effects of human PD-1 and CTLA-4 on immune responses, tumor development, and potential therapeutic interventions. The model undergoes thorough validation to ensure the appropriate expression of human targets, providing researchers with a reliable platform for studying immune checkpoint blockade and exploring novel treatment approaches.
