mLY6068
Model Information:
This model was developed from a tumor in the thyroid of a C57BL/6 mouse carrying the Igh-Myc mutation. The primary tumor developed at ~21 weeks of age. Expression of the mouse Myc transgene is restricted to the B cell lineage. Hemizygotes show increased pre-B cells in the bone marrow throughout life and a transient increase in large pre-B cells in the blood at 3-4 weeks of age. Spontaneous pre-B and B cell lymphomas reach an incidence of 50% at 15-20 weeks in hemizygous progeny of a wildtype female mated with a hemizygous male.
| Summary |
|
| Cancer Type |
Lymphoma |
| Mutations |
IgH-Myc TG (Eµ Myc) |
| Biopsy Site |
Thymus, thyroid and axillary lymph nodes |
| Pathology QC |
Undifferentiated sarcoma (Pa), diffuse large B cell lymphoma(DLBCL) with hemorrhagic necrosis ( P4) |
| Mouse Strain |
C57BL/6 |
| TMA |
TMA-MP-MX-001 |
Growth Characteristics
Additional Characteristics
