mLY6169

This model was developed from a tumor in the thyroid of a C57BL/6 mouse carrying the Igh-Myc mutation. The primary tumor developed at ~15 weeks of age. Expression of the mouse Myc transgene is restricted to the B cell lineage. Hemizygotes show increased pre-B cells in the bone marrow throughout life and a transient increase in large pre-B cells in the blood at 3-4 weeks of age. Spontaneous pre-B and B cell lymphomas reach an incidence of 50% at 15-20 weeks in hemizygous progeny of a wildtype female mated with a hemizygous male.