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Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.
Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.
Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.
Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.
Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.
Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.
Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.
Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.
Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.
Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.
Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.
Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.
Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.
Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.
Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.
Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.
Certified CRO services with NanoString GeoMx Digital Spatial Profiling.
De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.
Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.
Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.
Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.
Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.
Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.
Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.
Learn more about how our consulting services can help to support your journey to the clinic.
Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.
Learn more about the impact we make through our scientific talent, high-quality standards, and innovation.
We build a sustainable future by supporting employee growth, fostering leadership, and exceeding customer needs. Our values focus on innovation, social responsibility, and community well-being.
We build a sustainable future by fostering leadership, employee growth, and exceeding customer needs with innovation and social responsibility.
Our Scientific Advisory Board of experts shapes our strategy and ensures top scientific standards in research and development.
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Join us for a fast-paced career addressing life science needs with innovative technologies. Thrive in a respectful, growth-focused environment.
Access our latest scientific research and peer-reviewed articles. Discover cutting-edge findings and insights driving innovation and excellence in bioscience.
Discover valuable insights and curated materials to support your R&D efforts. Explore the latest trends, innovations, and expertly curated content in bioscience.
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Our non-GLP biofluid tests provide robust, high-quality data for early-stage preclinical drug development. These services provide a rapid, cost-effective way to analyze blood and urine samples as a standalone service, or supplementary to in vivo studies.
Analytes listed in the following sections are subject to change. Please contact your local business development specialist for our current offerings. Additional assays are available with a validation lead time of approximately 2-3 weeks.
Gain valuable information about drug efficacy, candidate selection, MoA, and enzymatic activity using a comprehensive portfolio of clinical chemistry assays developed on the Beckman Coulter® AU480 Chemistry Analyzer and Sysmex BX-3010 Automatic Chemistry Analyzer.
Alanine aminotransferase (ALT) | Hemoglobin A1C (HBA1c) |
Aspartate aminotransferase (AST) | Homocysteine |
Albumin (ALB) | Ion-specific electrode (ISE: Na, K, CL) |
Alkaline Phosphatase (ALP) | Iron |
Beta-2-Microglobulin (B2M) | Lactate dehydrogenase (LDH) |
Bicarbonate (CO2) | LDL Cholesterol |
Calcium | Lipemia, Icterus, Hemolysis (LIH) |
Cholesterol | Lipase |
C-Reactive Protein (CRP) | Magnesium |
Creatine Kinase | Urine Total Protein (MTP) |
Creatinine | Phosphorus |
CYSC | Total Bilirubin |
Direct Bilirubin | Triglyceride |
GGT (Gamma-Glutamyltransferase) | Urea Nitrogen (BUN) |
Glucose | Uric Acid |
HDL Cholesterol | Urine Albumin |
Platform:
White Blood Cell Count (WBC) |
Lymphocytes (LYM) |
Monocytes (MON) |
Neutrophils (NEU) |
Percentage of White Blood Cells (WBC%) |
Percentage of Lymphocytes (LYM%) |
Percentage of Monocytes (MON%) |
Percentage of Neutrophils (NEU%) |
Red Blood Cell Count (RBC) |
Hematocrit (HCT) |
Mean Corpuscular Volume (MCV) |
Red Cell Distribution Width (coefficient of variation) (RDWc) |
Red Cell Distribution Width (standard deviation) (RDWs) |
Hemoglobin (HGB) |
Mean Corpuscular Hemoglobin (MCH) |
Mean Corpuscular Hemoglobin Concentration (MCHC) |
Platelet Count (PLT) |
Mean Platelet Volume (MPV) |
Platelet Crit (PCT) |
Platelet Distribution Width (coefficient of variation) (PDWc) |
Platelet Distribution Width (standard deviation) (PDWs) |
Translational biomarkers are used throughout drug development to help elucidate underlying pathophysiology, understand an agents’ mechanism of action, measure efficacy, and stratify patient populations. We provide a panel of routinely performed immunoassay services to inform decision-making in drug development, as well as developing, validating, and performing custom assays.
Run your samples on MSD’s electrochemiluminescence technology platform. Using the Sector S 600, biomarkers can be customized into a V-PLEX or U-PLEX plate with up to 10 biomarkers of your choice.
Rodent Assays | Human and Nonhuman Primate Assays (NHP Valided Kits) |
---|---|
Mouse Adiponectin | 4-Spot Prototype Human Insulin, C-Peptide for NHP |
Mouse IL-1b | Human/NHP Glucagon |
Mouse IL-2 | Human/NHP Adiponectin |
Mouse IL-4 | Human/NHP Total GIP |
Mouse IL-5 | Human/NHP Insulin |
Mouse IL-6 | NHP Total GLP-1 (ver. 2 Kit) |
Mouse IL-10 | |
Mouse Leptin | |
Mouse MIP-3a | |
Mouse Pro-inflammatory 7plex, tissue culture | |
Mouse Pro-inflammatory Panel 1 (IFN-ץ, IL-1β, IL-2, IL-4, IL-5, IL-6, KC/GRO, IL-10, IL-12p70 and TNF-α) |
|
Mouse TGFB1 | |
Mouse TNF-a | |
Mouse/Rat GLP-1 (7-36 amide) | |
Mouse/Rat Glucagon | |
Mouse/Rat Insulin | |
Mouse/Rat Insulin/Glucagon | |
Mouse/Rat Total Active GLP1, Insulin, Glucagon | |
Mouse/Rat Total GLP-1 | |
Rat BNP | |
Rat IL-1a | |
Rat IL-1b | |
Rat IL-4 | |
Rat IL-5 | |
Rat IL-6 | |
Rat IL-13 | |
Rat Kidney Injury Panel 1 (Urine Albumin, KIM-1, NGAL/LCN2, Osteopontin) |
|
Rat MCP-1 | |
Rat Pro-inflammatory Panel 2 (IFN-γ, IL-10, IL-13, IL-1β, IL-4, IL-5, IL-6, KC/GRO, TNF-α) |
|
Rat TNF-a |
Evaluate biomarkers on our standard, colorimetric, enzyme-based ELISA platform.
Rodent Assays | Human and NHP Assays |
---|---|
Mouse Hydroxyproline | Human Cortisol |
Mouse Urine Albumin | Human IGFBP-1 |
Mouse/Rat Corticosterone | Human STELLUX Chemi Insulin |
Mouse/Rat/Human Free Glycerol | |
Rat Alpha-Fetoprotein | |
Rat Fecal Corticosterone Cayman | |
Rat Growth Hormone | |
Rat TGFB1 | |
Rat Urine Albumin | |
Rodent STELLUX Chemi Insulin |
Service Details
Turn Around Time: 5-7 business days (clinical chemistry), 7-10 business days (MSD & ELISA) Data Delivery Format: Excel File, unless otherwise requested
Assay Validation
To ensure you receive reliable data, we perform rigorous quality control and assay qualification procedures to ensure precision and accuracy. Our high quality results enable you to make preclinical go/no-go decisions with confidence.
Crown Bioscience's custom-fit, 7-point standard curves used to calculate accurate and precise concentrations for IL-10 and TNF-α.
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2023-09-10
2023-04-05
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