Tech Talk Series: In Vivo Solutions for Oncology Drug Development

Presented by: Rajendra Kumari, PhD

Watch this talk to learn about:

• Understanding limitations and strengths to help select the right models for drug development
• Predicting clinical response and representing patient diversity
• Challenges of modeling I/O, drug resistance, and advanced stages of cancer

Presented by: Gerold Feuer, PhD

Watch this talk to learn about:

• Comparison of MiXeno™ and HuCD34+ humanized mouse models for in vivo oncology studies
• Evaluating I/O therapies in humanized mice
• Engraftment of cell line-derived xenografts (CDX) and patient-derived xenografts (PDX) in humanized mouse platforms

Presented by: Sheng Guo, PhD

Watch this talk to learn about:

• Determining the optimal number of PDX models and mice per model to reach the goals of your mouse clinical trial
• Quantifying and evaluating your drugs’ efficacy in a mouse clinical trial
• Leveraging biomarker discovery in your study design

Presented by: Yinfei Yin, PhD

Watch this talk to learn about:

• The value of orthotopic and metastatic models in oncology research
• Establishing clinically relevant oncology models using optical imaging
• Advantages of high-frequency ultrasound for establishing clinically relevant oncology models