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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Tissue

Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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KRAS

Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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EGFR

Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Target to Lead Selection for ADCs and Biologics

Journey through the drug discovery pipeline from target discovery to in vivo pharmacology. Take advantage of the Largest biobank of patient-derived models, Model development capabilities, Cell-based assays for Screening ADCs, and advanced downstream analysis.

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Immuno-oncology Targets & Combinations

Leverage comprehensive in vitro, in vivo, ex vivo, and in silico platforms, utilizing immunocompetent, humanized, or patient-derived models. With robust biomarker analysis and a focus on checkpoint inhibitors, you can optimize combination strategies.

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Bioinformatics

Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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CRISPR/Cas9

Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Genomics

Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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Biomarker Discovery

De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Laboratory Services

Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.

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Pharmacology & Bioanalytical Services

Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Screens

Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Toxicology

Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Preclinical Consulting Services

Learn more about how our consulting services can help to support your journey to the clinic.

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Our Company

Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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Our Purpose

Learn more about the impact we make through our scientific talent, high-quality standards, and innovation.

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Our Responsibility

We build a sustainable future by supporting employee growth, fostering leadership, and exceeding customer needs. Our values focus on innovation, social responsibility, and community well-being.

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Meet Our Leadership Team

We build a sustainable future by fostering leadership, employee growth, and exceeding customer needs with innovation and social responsibility.

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Scientific Advisory Board

Our Scientific Advisory Board of experts shapes our strategy and ensures top scientific standards in research and development.

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News & Events

Stay updated with Crown Bioscience's latest news, achievements, and announcements. Check our schedule for upcoming events and plan your visit.

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Career Opportunities

Join us for a fast-paced career addressing life science needs with innovative technologies. Thrive in a respectful, growth-focused environment.

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Scientific Publications

Access our latest scientific research and peer-reviewed articles. Discover cutting-edge findings and insights driving innovation and excellence in bioscience.

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Resources

Discover valuable insights and curated materials to support your R&D efforts. Explore the latest trends, innovations, and expertly curated content in bioscience.

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Blogs

Explore our blogs for the latest insights, research breakthroughs, and industry trends. Stay educated with expert perspectives and in-depth articles driving innovation in bioscience.

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On Demand Webinar

What's Next in Preclinical Cancer Immunotherapy Research?

Speakers: Gera Goverse, PhD, Ludovic Bourre, PhD, Leo Price, PhD

The webinar features a panel discussion of key topics in the field of cancer immunotherapy, including new and emerging methods, recent publications, and future directions. The links between preclinical research, in vivo studies, and biomarkers will be explored, as well as the unique advantages of Crown Bioscience and their service offerings.

 

Watch this educational and webinar to learn about:

  • How our understanding of the cancer immunity cycle impacts cancer immunotherapy development

  • Which new in vitro technologies provide more physiological and translatable drug responses

  • Why HCI is providing deeper insights into drug responses

  • What novel solutions are on the horizon to overcome the challenges of immunotherapeutic development

About The Presenters:


Gera Goverse, PhD, Director, Immuno-oncology, Crown Bioscience

Dr. Gera Goverse joined OcellO in 2017 and is Director of Immuno-Oncology at Crown Bioscience Netherlands. Her expertise is in assay development for testing drug candidates targeting the immune cell response leading to the killing of tumors in 3D high content image assays. Dr. Goverse who obtained her PhD in Immunology at the VU Medical Centre Amsterdam and continued her post-doctoral studies at the KU Leuven, applies her obtained knowledge within these complex assays studying different subsets of immune cells and is specialized in the role of the myeloid cell compartment.


Ludovic Bourre, PhD, Vice President, Research & Innovation, Crown Bioscience

Ludovic serves as Executive Director leading the Scientific Engagement department. He has over 15 years of Oncology R&D experience. Prior to joining Crown Bioccience, he worked at Invectys (Paris, France) as head of the pharmacology, leading the preclinical and clinical evaluation of immuno-oncology programs. Ludovic holds a PhD in Pharmacology from Nantes University (France), and served as a postdoctoral researcher in University College London and University College Cork.


Leo Price, PhD, Senior Vice President, In Vitro, Head of Crown Bioscience Netherlands 

Leo Price leads Crown Bioscience’s in vitro services in Europe and the US and the Crown Bioscience sites in The Netherlands, Leiden and Utrecht. He joined Crown Bioscience in 2021 from OcellO, following Crown Bioscience’s acquisition of the company. Dr Price was the founder of OcellO, a leading provider of high content screening services, using organoids and other advanced 3D cell culture models, and served as their CEO and CSO for ten years. Prior to founding OcellO, Leo was a Faculty Member and Group Leader at Leiden University for five years and completed three postdoctoral studies with UMC Utrecht, The Netherlands Cancer Institute and Scripps Research Institute. He received his PhD in Cell Physiology from University College London and is currently a guest Associate Professor at the Leiden Academic Centre for Drug Research, Leiden University.



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