AACR 2023 Poster 185

Global Mapping of Pathway Modules and Phosphorylation Networks in PDX and Corresponding Organoid (PDXO) Models Treated with Targeted Therapies

Martin Mehnert^1*, Xiaoxi Xu^2*, Binchen Mao², Tobias Treiber¹, Limei Shang², Leilei Chen², Jessie Wang², Marco Tognetti¹, Christopher Below¹, Roland Bruderer¹, Jakob Vowinckel¹, Wubin Qian², Yanghui Sheng², Sheng Guo², Ludovic Bourré², Yuehan Feng¹. ^*These authors contributed equally

¹Biognosys AG, Wagistrasse 21, 8952 Schlieren, Switzerland;
²Crown Bioscience Inc., 16550 West Bernardo Drive, Building 5, Suite 525, San Diego, CA 92127, USA

Multi-omics-based strategies in precision medicine, including genomic, transcriptomic and proteomic data, have contributed to the molecular-level characterization of cancers and the identification of novel driver genes, as well as a better comprehension of resistance mechanisms. Patient-derived tumor models, including patient-derived xenograft (PDX) and in vitro 3D organoid counterparts (PDXO), are widely recognized as predictive preclinical cancer models closely recapitulating both tumor complexity and patient response and enabling the study of tumor identity for personalized medicine

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• The potential of multi-omics-based strategies in precision medicine using patient-derived tumor models 
  
  
• How deep global-proteomic and phospho-proteomic analysis can be used to investigate drug response in PDX and PDXO models.
  
  
• How pathway analysis and kinase enrichment analysis can provide insights into the mechanism of action and resistance mechanism of drugs tested on PDX and PDXO models

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