AACR 2024 Poster 2827

Characterization of Acute Myeloid Leukemia PDX Models with Hotspot Gene Mutations for Therapeutic Evaluation

Qingzhi Liu, Jinxi Wang, Jinping Liu, Likun Zhang, Ludovic Bourre, Jessie J.J. Wang

Acute myeloid leukemia (AML) is the most common acute type of leukemia in adults characterized by chromosomal abnormalities and gene mutations. While inhibitors have shown promise the emergence of drug resistance poses a significant challenge.

In this study, a panel of AML PDX models with multiple gene alterations was established to support the development of new therapies.

The results of this study showed the establishment of a panel of AML PDX models, including different subtypes and genomic features reflecting the clinic. Those models will support the preclinical evaluation of new treatments or combination modalities as well as a better understanding of drug resistance mechanisms.

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• Study method involving establishment of nine systemic and one subcutaneous AML PDX models carrying hotspot mutations, showing comparable features to the clinic.
• Effect of study treatments on models carrying hotspot mutations in terms of tumor burden reduction and survival increase.
• The result that Gilteritinib, a type Ⅰ FLT3i, had on overcoming resistance.

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