AACR 2024 Poster 538

Establishment of PARP Inhibitor-Induced Resistant Patient-Derived Ovarian Cancer Xenograft Models

Aaron Li Hua, Chenpan Nie, Bonnie Xiaobo Chen, Guo Sheng, Ludovic Bourre, Jessie JingJing Wang

This poster describes how Patient-Derived Xenograft models resistant to PARP Inhibitors were generated. Despite encouraging efficacy of these PARP inhibitors, acquired resistance, such as HR repair restoration, drug efflux pump upregulation and replication fork protection, has limited their clinical benefits. Therefore, to investigate novel therapeutic strategies which can overcome the acquired resistance, patient-derived xenograft (PDX) ovarian cancer models with PARP inhibitor-induced resistance were established. Finally, this model was used to investigate the potential mechanism of resistance in ovarian cancer models.

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• Methods used to establish PARP Inhibitor-Induced Resistant PDX models
• RNA-seq methods revealing potential mechanisms of resistance
• Tumor growth curves of established models

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