AACR 2024 Poster 5264

KRAS^G12C Inhibition Synergizes with Checkpoint Blockade in KRAS^G12C-Mutated Tumor Model

Aaron Li Hua, Jian Feng, Chenpan Nie, Chenfei Zhang, Annie Xiaoyu An, Ludovic Bourre, Jessie JingJing Wang

This poster describes the synergistic effects of Sotorasib with a checkpoint inhibitor on a model harboring the KRAS^G12C mutation. To evaluate novel therapeutic strategies for treating KRAS^G12C-mutated tumors, a CT26-KRAS^G12C tumor model was established using CRISPR/Cas9 and the combination of AMG510 with anti-PD1 therapy was explored by measuring cell proliferation, tumor growth, and immune profiling.

The study presented in this poster compares the two approaches.

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• CRISPR Methods used to generate a CT26 KRAS 12C tumor model
• Tumor model response to Sotorasib and anti-PD1 combination in comparison to Sotorasib treatment alone
• Immune profiling of tumors of CT26 KRAS 12C tumor model treated with Sotorasib and checkpoint inhibitor

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