AACR 2024 Poster 4179

Magnetic Resonance Imaging and Bioluminescence Imaging for Evaluating Tumor Burden in Orthotopic Glioblastoma

Guo Mingrui, Ruisong Su, Jeff Chor, Zheyan Zhang, Mandy Tan, Xing Qi Teo, Haosheng Feng, Kuan Jin Lee, Aaron Hua, Longyun Zhang, Jie Cai, Guanping Mao, Jessie (Jingjing) Wang, Keefe Chng, Weiping Han, Colin Guo

Accurate monitoring of orthotopic tumors in oncological research is critical. Common imaging methods including bioluminescence imaging (BLI), ultrasound imaging (US,) and computed tomography (CT) each have advantages and limitations.

MRI has been introduced as a modality to overcome these limitations. This study compares BLI and MRI in tracking tumor progression, focusing on the human glioblastoma multiforme (GBM) orthotopic xenograft mouse model.

MRI-based tumor tracking opens the possibility to use more clinically relevant patient derived xenograft (PDX) models of GBM in an orthotopic manner, improving the clinical transability to evaluate new GBM treatment modalities.

Download this Poster to Discover:

• Method to establish the GBM model, and assessing In-life tumor growth
• Results from both BLI and MRI – looking at tumor growth
• Advantages of MRI over BLI for longitudinal monitoring of orthotopic GBM models

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