ANE 2023 Poster A016

Novel LEF1 Gene Structural Variants in T Cell Acute Lymphoblastic Leukemia Patient-derived Xenograft Models

Yueying Wang, Wubin Qian, Mengting Qin, Xiaobo Chen, Jia Xue, and Sheng Guo

Crown Bioscience Inc., 218 Xinghu Street, Suzhou, Jiangsu, 215000, China

T cell acute lymphoblastic leukemia (T-ALL) is marked by intricate genetic factors, among which the LEF1 transcription factor stands prominent. Our research delves deep into the influence of LEF1 and its link to the MYC proto-oncogene, revealing structural variants (SVs) in PDX models that may offer therapeutic potential.

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• LEF1's pivotal role in T-ALL and its interplay with MYC.
  
  
• Innovative use of OGM and WGS to identify LEF1 SVs.
  
  
• How novel LEF1 SVs might influence MYC expression, suggesting therapeutic avenues.

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