CICON 2023 Poster 341

Prevention of Terminal T Cell Exhaustion Features by Treatment With Chromatin Remodeling Inhibitors

Eden Kleiman^1,2, Linda Liang¹, Jared Gunn¹, Mingfa Zang ¹, Marrit Putker¹, Ludovic Bourre¹ and Pirouz Daftarian<sup>1,2

1</sup>Crown Bioscience, Inc ., 16550 West Bernardo Drive, Building 5, Suite 525, San Diego, CA
^{1 2}JSR Life Sciences, Sunnyvale, CA

This research, presented during a poster session at CICON23, presents an in vitro assay with key hallmarks for T cell exhaustion to assess impact of candidate drugs on T cell differentiation and function.

In this study, the SMARCA4/2 ATPase inhibitor FHT-1015 as well as two Proteolysis Targeting Chimera compounds (PROTACs), ACBl1 and AU-15530 were tested.

Chromatin remodeling inhibitor FHT-1015 was found to reduce most of these key hallmarks of T cell exhaustion in this in vitro setting.

Download this Poster to Discover:

• Effect of the SMARCA4/2 ATPase inhibitor FHT-1015 as well as two Proteolysis Targeting Chimera compounds (PROTACs), ACBl1 and AU-15530 on T cell differentiation and function
  
  
• How this in vitro assay setup can be used to screen immunomodulatory drugs for their ability to prevent, slow down or potentially even reverse functional and immunophenotypic markers of T cell exhaustion.

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