ENA 2024 Poster 277

Comparative Analysis of Immune Responses in a 3D Ex Vivo Patient Tissue Platform Across Diverse Cancer Types

Ezgi Kaya Aksoy, Sander Basten, Jolie Flach, Niels Meesters, Talita Stessuk, Luca Gandini, Emma Spanjaard, Leo Price and Nataliia Beztsinna

The intricate interactions between immune and tumor cells are essential in cancer immunotherapy research but are difficult to replicate accurately in vitro and in vivo. Traditional 2D cell cultures often fail to mimic the tumor microenvironment (TME) and the complexity of cancer-immune cell dynamics.

To address this gap, we have developed the 3D Ex Vivo Patient Tissue (EVPT) platform. This study compares the responses of ex vivo tumor samples from various indications, of which some are considered as “cold” or “hot”, to immuno-oncology therapies and explores the heterogeneity of responses across different cancer types in the EVPT platform.

Download this Poster to Discover:

• The most patient-relevant translational system that uses fresh patient samples, which preserves the native TME, including resident immune cells
• How the response of NSCLC samples to immune checkpoints inhibitors correlates with clinical response rates
• How EVPT can be used to assess the differential response between cancer types

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