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Bladder Cancer PDX Models

With many new agents under development, including immuno- and targeted therapies, predictive research models such as patient-derived xenografts (PDX) are required for preclinical evaluation. PDX models are proven to be highly predictive models for preclinical drug assessment. The Crown Bioscience bladder cancer PDX collection consists of a wide range of models, including subcutaneous and orthotopic models to more closely recapitulate the tumor microenvironment and models carrying FGFR3 and TSC1 mutations. More

PDX offer the most translational preclinical model for efficacy screening in cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, PDX models reflect the heterogeneity and diversity of the human patient population. PDX give you an accurate, predictive model of how your treatment will perform, well before entering into expensive clinical trials. Crown Bioscience's HuPrime® PDX models are well characterized for pathology, growth characteristics, and are also genetically/genomically annotated for gene expression, gene copy number, mutations, and fusions.

MODEL NUMBER CANCER TYPE CANCER SUBTYPE DESCRIPTION # per page
BL0597 Bladder Cancer SCC Poorly to moderately differentiated squamous cell carcinoma CLICK TO VIEW
BL2350 Bladder Cancer ADC Urachal adenocarcinoma CLICK TO VIEW
BL2393 Bladder Cancer Sarcoma Spindel cell tumor of bladder. Consider liomyosarcoma on basis of IHC results. The tumor is lined in bundles, mitotic figure: 13-17/10 HPF, infiltrated through bladder wall. CLICK TO VIEW
BL3249 Bladder Cancer SCC Bladder: infiltrative urothelial carcinoma with squamous differentiation and adenoid differentiation, tumor invasive to adventitia of bladder and form cancer node. CLICK TO VIEW
BL3325 Bladder Cancer ADC Bladder: infiltrative urothelial carcinoma, low grade. One of fourteen lymph nodes involved by metastatic carcinoma (1/14). CLICK TO VIEW
BL3338 Bladder Cancer ADC Adenocarcinoma CLICK TO VIEW
BL3479 Bladder Cancer NA Bladder: infiltrating urothelial carcinoma, high grade, infiltrating through bladder wall CLICK TO VIEW
BL3578 Bladder Cancer NA Bladder: infiltrating urothelial carcinoma, infiltrating through bladder wall CLICK TO VIEW
BL5001 Bladder Cancer TCC bladder carcinoma, transitional cell carcinoma, pd. Pathol comment: c/w diagnosis. approximately 80% of the tissue involved by malignant tumor in sections examined. malignant tumor cells present in cytospin prep. CLICK TO VIEW
BL5003 Bladder Cancer TCC bladder carcinoma, transitional cell carcinoma. Pathol comment: c/w diagnosis. approximately 80% of the tissue involved by malignant tumor in sections examined. malignant tumor cells present in cytospin prep. CLICK TO VIEW
BL5006 Bladder Cancer TCC bladder carcinoma, metastatic transitional cell bladder cancer. Pathol comment: c/w diagnosis. approximately 80% of the tissue involved by malignant tumor in sections examined. malignant tumor cells present in cytospin prep. CLICK TO VIEW
BL5007 Bladder Cancer TCC bladder carcinoma, transitional cell carcinoma. Pathol comment: c/w diagnosis. approximately 10% of the tissue involved by malignant tumor in sections examined. focal tumor necrosis. malignant tumor cells present in cytospin prep. CLICK TO VIEW
BL5368 Bladder Cancer NA Bladder Cancer. Pathol comment: c/w diagnosis. Microscopic focus of malignant tumor present in tissue sections examined. Malignant tumor cells present in cytospin prep. CLICK TO VIEW
BL5384 Bladder Cancer NA Bladder Carcinoma. Pathol comment: c/w diagnosis. Approximately 50% of the tissue involved by maligmant tumor in sections examined. 10% necrotic. Malignant tumor cells in cytospin prep. CLICK TO VIEW
BL5420 Bladder Cancer NA Oat cell CLICK TO VIEW
BL5422 Bladder Cancer NA Bladder Carcinoma. Pathol comment: Tumor cells present in cell block and cytospin prep. CLICK TO VIEW
BL5425 Bladder Cancer NA Bladder carcinoma. Pathol comment: Approximately 70% of the tissue involved by maligmant tumor in sections examined. Malignant tumor cells present in cytospin prep. CLICK TO VIEW
BL5428 Bladder Cancer NA Bladder Carcinoma. C/W DIAGNOSIS. APPROXIMATELY 50% OF THE TISSUE INVOLVED BY MALIGNANT TUMOR IN SECTIONS EXAMINED. MALIGNANT TUMOR CELLS PRESENT IN CYTOSPIN PREP. CLICK TO VIEW
BL9200 Bladder Cancer NA NA CLICK TO VIEW
BL9201 Bladder Cancer N/A N/A CLICK TO VIEW
BL9208 Bladder Cancer NA NA CLICK TO VIEW
BL9210 Bladder Cancer NA NA CLICK TO VIEW
BL9211 Bladder Cancer N/A N/A CLICK TO VIEW
BL9212 Bladder Cancer NA NA CLICK TO VIEW
BL9213 Bladder Cancer NA NA CLICK TO VIEW
BL9214 Bladder Cancer NA NA CLICK TO VIEW
BL9216 Bladder Cancer N/A N/A CLICK TO VIEW
BL9217 Bladder Cancer N/A N/A CLICK TO VIEW

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