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Patient-Derived Xenograft Models of Lung Cancer

Lung cancer is the most common type of cancer worldwide, accounting for 13% of the total number of new diagnoses and is classified according to histological type by the size and appearance of cells: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Given the prominence of lung cancer diagnosed in the population, predictive preclinical models are essential for treatment development. Our lung cancer models are known to be the most predictive and provide the most accurate approach to evaluating an agents efficacy prior to entering the clinic. Crown Bioscience offers a large collection of over 300 well characterized models including 70 SCLC models, as well as primary and metastatic models. More

Benefits of Crown Bioscience's Lung Cancer PDX Models

Our lung cancer patient-derived xenograft models offer the most translational preclinical model for efficacy screening in cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, patient derived xenografts reflect the heterogeneity and diversity of the human patient population. PDX give you an accurate, predictive model of how your treatment will perform, well before entering into expensive clinical trials. Crown Bioscience's HuPrime®  PDX models are well characterized for pathology, growth characteristics, and are also genetically/genomically annotated for gene expression, gene copy number, mutations, and fusions.

MODEL NUMBER CANCER TYPE CANCER SUBTYPE DESCRIPTION # per page
LU0009 Lung Cancer NSCLC, SCC Squamous cell carcinoma of right lung, central type with massive necrosis, moderately differentiated, tumor mass: 10cm x 6cm x 5cm. Regional LN: paratracheal LN (2/6). IHC results: HER-1(-), HER-2(-), p53(+ >75%), p170(-), Ki-67(+ 25~50%), p63(+ >75%), VEGF(+), Top-IIa(+ 25~50%), p16(-). CLICK TO VIEW
LU0038 Lung Cancer NSCLC, SCC Squamous cell carcinoma of left lung, grade I-II, tumor mass: 4.5cm x 4cm x 5cm. No maglignant cells adjacent to bronchial stump. Regional LN: hilum of lung LN (0/4), LN of inferior pulmonary ligament (0/2), carina of trachea LN (0/2), LN of left pulmonary vein (2/6). CLICK TO VIEW
LU0299 Lung Cancer NSCLC, SCC Squamous cell carcinoma of lung, no visible malignant cells adjacent to upperside and downside of surgery cut, no malignant cells in LN of hilum of lung LN (0/2) and eminence LN (0/4). CLICK TO VIEW
LU0330 Lung Cancer NSCLC, SCC Squamous cell carcinoma of lung, moderately differentiated. CLICK TO VIEW
LU0350 Lung Cancer NSCLC, SCC Squamous cell carcinoma of lung, no visible malignant cells adjacent to bronchus stump, no malignant cells in LN of inferior pulmonary. veins LN (0/1), subeminence LN (0/3). CLICK TO VIEW
LU0357 Lung Cancer NSCLC, SCC Squamous cell carcinoma of lung, no visible malignant cells adjacent to bronchial stump. Regional LN: hilum of lung LN (0/2), the second hilum of lung (0/2), superior mediastinal LN (0/1), inferior carina of trachea LN (0/2), anterior tracheal LN (0/1). CLICK TO VIEW
LU0367 Lung Cancer NSCLC, SCC Squamous cell carcinoma of lung, no visible malignant cells adjacent to superior stump, no malignant cells in LN of hilum of lung LN (0/8), eminence LN (0/5), paratracheal LN (0/7), inferior pulmonary veins LN (0/1). CLICK TO VIEW
LU0377 Lung Cancer NSCLC, ADC Adenocarcinoma of lung, poorly differentiated, no visible malignant cells adjacent to bronchial stump. Regional LN: hilum of lung LN (0/3), the second hilum of lung LN (0/2), carina of trachea LN (0/1). CLICK TO VIEW
LU0387 Lung Cancer NSCLC, ADC Adenocarcinoma of lung, malignant cells adjacent to bronchial stump. Regional LN: superior mediastinal LN (2/2), inferior carina of trachea LN (1/1), subclavian LN (1/1), hilum of lung LN (3/3), second hilum of lung LN (0/2). CLICK TO VIEW
LU0395 Lung Cancer NSCLC, SCC Adenoacanthoma of lung, no visible malignant cells adjacent to bronchus stump, malignant cells in superior mediastinum LN (1/3), eminence LN (0/2), inferior pulmonary ligament (0/2), and hilum of lung LN (1/2). CLICK TO VIEW
LU0697 Lung Cancer NSCLC, SCC Squamous cell carcinoma of lung. No malignant cells adjacent to bronchus stump. Regional LN: superior mediastinal LN (0/6), inferior carina of trachea LN (0/1). CLICK TO VIEW
LU0741 Lung Cancer NSCLC, SCC Squamous cell carcinoma of lung. No malignant cells adjacent to bronchial stump. Regional LN: LN between lobules of lung (0/2), inferior pulmonary vein LN (0/1), superior mediastinal LN (0/6), subclavian LN (0/2), carina of trachea LN (0/4), right hilum of lung LN (2/2). Tumor embolus were observed in inferior pulmonary vein. CLICK TO VIEW
LU0743 Lung Cancer NSCLC, SCC Squamous cell carcinoma of lung. No malignant cells adjacent to bronchial stump. Regional LN: inferior pulmonary vein LN (0/1), paraaotic LN (0/6), hilum of lung LN (1/6), inferior carina of trachea LN (1/3). Malignant cells invaded pericardium and fiber of chest wall. CLICK TO VIEW
LU0748 Lung Cancer NSCLC, SCC Squamous cell carcinoma of lung. CLICK TO VIEW
LU0755 Lung Cancer NSCLC, SCC NA for clinical diagnosis info. CLICK TO VIEW
LU0858 Lung Cancer NSCLC, SCC Squamous cell carcinoma of lung, poorly differentiated. No malignant cells adjacent to bronchus stump. Regional LN: hilum of lung LN (0/2), superior mediastinal LN (0/2), the tenth group LN (0/5). CLICK TO VIEW
LU0860 Lung Cancer Neurofibroma NA for clinical diagnosis info. CLICK TO VIEW
LU0861 Lung Cancer NSCLC, SCC Squamous cell carcinoma of lung. No maglignant cells adjacent to bronchial stump. Regional LN: hilum of lung LN (0/1). CLICK TO VIEW
LU0876 Lung Cancer NSCLC, SCC NA for clinical diagnosis info. CLICK TO VIEW
LU0884 Lung Cancer NSCLC, SCC Squamous cell carcinoma in lung. Malignant cells adjacent to bronchus stump. Regional LN: hilum of lung LN (0/1), the second hilum of lung LN (0/2), superior mediastinal LN (0/2), carina of trachea LN (0/2), LN between lobules of lung (0/1). CLICK TO VIEW

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