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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Tissue

Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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KRAS

Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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EGFR

Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Bioinformatics

Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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CRISPR/Cas9

Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Genomics

Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.

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Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Screens

Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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Symposium: Organoids and Beyond - Next Generation In Vitro Platforms for Preclinical Drug Discovery

Date: Thursday, December 1, 2022 | Talks: 10:00 am - 3:30 pm CET

Location: Rijksmuseum Boerhaave, Leiden, Netherlands

With the expansion of Oncology and Immuno-Oncology drug development, effective preclinical platforms are required for testing efficacy and safety of new targets. Matching a promising target to the best patient population requires an arsenal of tools, in depth expertise, and models that reflect the patient clinical situation as early as the in vitro stage of preclinical drug development.

In vitro technologies, especially within the Organoid space are revolutionizing Oncology Drug Discovery and Development. While there have been great advances there are still hurdles to overcome. Discover what is next for this innovative and disruptive technology and understand the key differences between 3D in vitro systems, such as cell lines and patient-derived models including organoids.

This symposium will bring together R&D and preclinical teams from pharmaceutical and biotech companies to facilitate cross-discipline discussions on current techniques and the application of future approaches. Learn how to select the right 3D in vitro platform for your drug development program based on model features, benefits, and limitations.

Key Discussion Areas:

  • How in vitro and Organoid platforms provide better insights for oncology and immunotherapy studies
  • Which innovative in vitro platforms offer superior outcomes to alternative approaches
  • What’s on the horizon for Organoid and in vitro technology
  • 3D workflow optimization, new ideas, trends, and innovation.

Join us for a full agenda of talks from the leading researchers in this rapidly developing area, followed by an opportunity to network with your peers at a complimentary drink’s reception

Register Now!

Attendance for the symposium is free but space is limited.  We encourage early registration.
Lunch will be served. 


Speakers

Anita Seshire

Senior Innovation Manager, Strategic Innovation and Head of Laboratory in Oncology,
Merck Healthcare

Talk Title: Multicellular 3D models to tackle translational questions in cancer research

Paul Vulto

Chief Executive Officer & Co-founder, Mimetas

Talk Title: Grow, Learn, Discover: how phenotypic modelling is changing the way we discover new medicines

Willemijn Vader

CEO, VitroScan B.V.

Talk Title: An ex vivo tumor testing platform to (r)evolutionize patient stratification

Andrea Bisso

Associate Director Pharmacology & Pre-Clinical development, Gadeta B.V.

Talk Title: Exploiting gamma delta TCR targeting to enable safe and effective cell therapies for solid tumors

Bram Herpers

Executive Director, General Manager, Crown Bioscience Netherlands

Talk Title: Identifying Clinical Candidates with Cancer Organoids

Gustave Ronteix

Gustave Roussy Institute

Talk Title: A multiscale droplet microfluidics platform for identifying immune-tumour interactions.

Delilah Hendriks

Senior Postdoctoral Fellow, Clevers lab, Hubrecht Institute

Talk Title: Human liver organoids as a platform for liver disease modelling

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