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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Tissue

Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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KRAS

Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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EGFR

Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Bioinformatics

Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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CRISPR/Cas9

Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Genomics

Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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Biomarker Discovery

De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Laboratory Services

Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.

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Pharmacology & Bioanalytical Services

Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Screens

Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Toxicology

Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Our Company

Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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Our Purpose

Learn more about the impact we make through our scientific talent, high-quality standards, and innovation.

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Our Responsibility

We build a sustainable future by supporting employee growth, fostering leadership, and exceeding customer needs. Our values focus on innovation, social responsibility, and community well-being.

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Meet Our Leadership Team

We build a sustainable future by fostering leadership, employee growth, and exceeding customer needs with innovation and social responsibility.

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Scientific Advisory Board

Our Scientific Advisory Board of experts shapes our strategy and ensures top scientific standards in research and development.

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News & Events

Stay updated with Crown Bioscience's latest news, achievements, and announcements. Check our schedule for upcoming events and plan your visit.

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Career Opportunities

Join us for a fast-paced career addressing life science needs with innovative technologies. Thrive in a respectful, growth-focused environment.

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Scientific Publications

Access our latest scientific research and peer-reviewed articles. Discover cutting-edge findings and insights driving innovation and excellence in bioscience.

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Resources

Discover valuable insights and curated materials to support your R&D efforts. Explore the latest trends, innovations, and expertly curated content in bioscience.

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Blogs

Explore our blogs for the latest insights, research breakthroughs, and industry trends. Stay educated with expert perspectives and in-depth articles driving innovation in bioscience.

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OrganoidXplore™: The first large panel based Organoid screening service

What is OrganoidXplore?

Fast-track your oncology drug candidate development with OrganoidXplore, our advanced platform optimized for comprehensive organoid panel screening. This assay-ready service processes up to 50 models in as little as 6 weeks ensuring your research stays ahead of the curve with rapid, data-driven decision making.  At the heart of this premier service is an extensive repository of thoroughly characterized PDO and PDXO models including significant mutational profiles. The service has been designed to provide detailed measurements of drug responses in both tumor and normal organoids. Moreover, it facilitates exploration into new cancer indications backed by validated targets and advanced biomarker analysis.

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Why do you need OrganoidXplore?

Key Area

Noteworthy Benefits

Model Selection Diversity Leverage 50 well-characterized PDO and PDXO models with varied genetic backgrounds and mutations such as KRAS, BRAF, and EGFR, enriching your research diversity.
Multiple Panel Options Choose from Full Panel, KRAS Panel, Lung Panel, CRC Panel, or Flexible Panel (20+ model selection).
Data Reliability Depend on rigorously validated and quality-assured organoid models, SNP verified and mycoplasma tested. Underpinned with extensive characterization against standard of care agents.
7 Cancer Type Models Explore and test efficacy across a diverse range of cancer types, including lung, breast, ovarian, colorectal, pancreatic, cervical, head and neck.
Comprehensive Analysis Investigate off-target effects with 6 matched normal/disease pairs, enabling a thorough comparative analysis.
PDX Model Selection Transition effortlessly into in vivo studies with the majority of our models. Elect suitable Patient Derived Xenograft models to validate your efficacy studies and accurately stratify patient responses. 
Accelerated Progress
Fast-Track Your Screen: 50 models, results in 6 weeks. Benefit from a short 5-day incubation time, facilitating timely results and accelerating your research timelines. Employ a Semi-Automated Workflow, ensuring accuracy and reproducibility across runs with the help of top of the line liquid handlers.

In-Depth Customer Report

Receive an exhaustive Customer Report featuring 9-point dose-response curves, IC50s, study design, control performance, ensuring you have all the data needed to proceed confidently in your research. 

Flexible options to customize your project
  • Drug Combination Studies:
    Opt for enhanced therapeutic potential through optional drug combination studies, opening new avenues for impactful research findings.

  • RNA-seq & Protein Expression Analysis:
    Follow up with sample collection services to further delve into RNA-seq and protein expression analysis, expanding your research dimensions.

  • Dynamic Biomarker Analysis:
    Integrate advanced biomarker analysis for early patient stratification, streamlining the clinical development of novel oncology drugs.

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