ADC 2024 Poster

Discovery to Translational Solutions Leveraging Patient-Derived Models for ADC Therapeutic Evaluation & Resistance Profiling

Chengcheng Wang, Peng Wang, Jinxi Wang, Jessie J.J. Wang, Xialong Tu, Yunping Liu, Jia Zheng, Kaixia Lian, Bulak Arpat, Sheng Guo, Rajendra Kumari, Luke Yu

Advances in ADCs formats such as bispecific ADCs, Probody drug conjugates, immune-stimulating ADCs, protein-degrader ADCs and dual-drug ADCs are providing novel approaches to overcome some of the challenges.

In this poster, we show how our integrated ADC platform leverages patient-derived model systems such as organoids, PDX or ex vivo tissue alongside standard cell line systems to better reflect tumor heterogeneity and patient diversity, thus increasing the potential for biomarker identification.

We describe how patient-derived systems can be leveraged for ADC target validation, therapeutic screening, tackling ADC resistance and guiding patient stratification.

Download this Poster to Discover:

• Methods for functional ADC screening using large organoid panels.
• How the combination of organoids with high content imaging provides key insights into ADC target engagement and mechanism of action.

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