AACR Poster 1503: Immune Cell Depletion Affects aPD-1 Efficacy

Effect of Immune Cell Depletion on Response to PD-1 Treatment in Syngeneic Models

Ying Jin, Yongli Shan, Chunkai, Li, Annie X. An, Henry Q. Li, Davy X. Ouyang

With the continued rise of immunotherapy, it is becoming critically important to fully understand which immune cell lineages play a major role in mediating PD-1 response, in any given tumor microenvironment.

It is already well-known that anti-PD-1 antibodies work via activation of cytotoxic T cells. However, the contribution of other immune cell populations to PD-1 treatment are not well defined.

To understand how different lineages of immune cells impact PD-1 efficacy, we depleted various immune cell subpopulations in MC38, CT-26, and Hepa 1-6 murine syngeneic models when treated with PD-1 antibody, with the initial results presented here.

Read this Poster to Discover:

• The effectiveness of immune cell depletion for CD4 T cells, CD8 T cells, Treg cells, NK cells, MDSC, and macrophages
  
  
• That depletion of CD8 T cells significantly attenuates anti-PD-1 treatment antitumor effects, confirming the crucial role of CD8 T cells in tumor killing
  
  
• That CD4+ T cell depletion induces contrary effects across the syngeneic models tested

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