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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Tissue

Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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KRAS

Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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EGFR

Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Bioinformatics

Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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CRISPR/Cas9

Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Genomics

Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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Biomarker Discovery

De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Laboratory Services

Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.

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Pharmacology & Bioanalytical Services

Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Screens

Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Toxicology

Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Our Company

Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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Our Purpose

Learn more about the impact we make through our scientific talent, high-quality standards, and innovation.

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Our Responsibility

We build a sustainable future by supporting employee growth, fostering leadership, and exceeding customer needs. Our values focus on innovation, social responsibility, and community well-being.

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Meet Our Leadership Team

We build a sustainable future by fostering leadership, employee growth, and exceeding customer needs with innovation and social responsibility.

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Scientific Advisory Board

Our Scientific Advisory Board of experts shapes our strategy and ensures top scientific standards in research and development.

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News & Events

Stay updated with Crown Bioscience's latest news, achievements, and announcements. Check our schedule for upcoming events and plan your visit.

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Career Opportunities

Join us for a fast-paced career addressing life science needs with innovative technologies. Thrive in a respectful, growth-focused environment.

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Scientific Publications

Access our latest scientific research and peer-reviewed articles. Discover cutting-edge findings and insights driving innovation and excellence in bioscience.

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Resources

Discover valuable insights and curated materials to support your R&D efforts. Explore the latest trends, innovations, and expertly curated content in bioscience.

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Blogs

Explore our blogs for the latest insights, research breakthroughs, and industry trends. Stay educated with expert perspectives and in-depth articles driving innovation in bioscience.

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Preclinical Biomarker Discovery

Preclinical Biomarker Discovery

Preclinical biomarker discovery strategies help to identify potential therapeutic targets, assess the safety and effectiveness of new compounds, and inform the design of clinical trials. If introduced early in preclinical studies, they can play a key role in reducing the cost and time required for drug development. 

Biomarkers can also help to identify subgroups of patients who are likely to respond to a particular therapy, which can inform the design of clinical trials and improve their chance of success.

Rely on our extensive experience and leverage our comprehensive resources for your preclinical studies. Our offerings include:

  • Preclinical Models and Databases: Access our wide range of in vivo and in vitro models, supported by comprehensive databases for baseline and historical data, essential for evaluating new therapeutic compounds.
  • Multiomics Biomarker Analysis: Explore biomarkers using our advanced genomics, proteomics, and metabolomics capabilities.
  • Experimental Design and Bioinformatics: Utilize our integrated tools for robust experimental design and efficient data analysis, ensuring precise and insightful research outcomes.

biomarker-strategy

Biomarker discovery via in vitro screening

 

In vitro screening is time and cost-efficient, and can provide useful information on drug target(s) and targeted pathways. Utilize it to:

•    Explore/validate your drug mechanism of action (MoA)
•    Identify genetic features associated with drug response on a set of cell lines/organoids
•    Develop single or composite biomarkers
•    Provide advice and guidance on future in vivo model selection

Fig. Example workflow of cell-based compound screening

Our in vitro model systems and screening services

Discover our cell line and organoid collections

Our expert team have extensive experience of partnering with clients to support the in vitro pharmacology characterization of lead compounds and are committed to saving you precious time and resources by providing efficient screening platforms and validated 2D and 3D models, giving you confidence in your data.

Learn More About Our In Vitro Models

OmniScreen™ Cell Based Screening Service

Biomarker discovery streamlined with OmniScreen

  • Well-validated, large-scale cell panel screening platform
  • Focused screening panels 
  • By cancer type
  • Mutation of interest
  • Availability of matched in vivo models
  • Quarterly enrollment
  • Cost effective: Positive drug control and cell line revival costs are included

Learn more about OminiScreen

OrganoidXplore™: The first large panel based Organoid screening service

Streamline oncology drug development with OrganoidXplore, offering rapid and detailed organoid screening to enhance research efficiency.

  • Efficient Screening: Up to 50 models in 6 weeks with a fast 5-day incubation.
  • Extensive Model Repository: Access to detailed PDO and PDXO mutational profiles for accurate drug response analysis.
  • Precision Service: Targets both tumor and normal organoids, supporting new cancer research with advanced biomarker analysis.
  • Automated Workflow: Guarantees reproducibility and accuracy.
  • In-depth Reporting: Includes comprehensive reports with critical study metrics.
  • Flexible Customization: Allows for drug combination studies, RNA-seq, protein analysis, and biomarker integration for broader research scope.

Learn More about OrgnoidXplore


Biomarker discovery via in vivo screening

 

In vivo screening using mouse models can mimic phase II clinical trials to provide accurate measurement of drug efficacy and is powerful for biomarker discovery due to its unique study designs. Utilize it to:

  • Explore/validate drug MoA
  • Identify genetic features associated with drug response on a set of PDX models
  • Develop single-gene or composite biomarkers
  • Provide advice and guidance on future clinical trials

Our in vivo model systems and screening services

Discover our animal model collection

World’s largest commercial collection of  Patient-derived xenografts (PDX) models, cell line-derived xenografts (CDX), syngeneic models, humanized models, immunocompetent chimeric mouse models, tumor homografts, and more.

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In vivo screening via mouse clinical trial

Preclinical population studies that help stratify patients for clinical trials

Learn More about Mouse Clinical Trial

In Vivo Screens for Evaluating Immunotherapies: MuScreen™

  • Cost-effective and time-efficient screen to fast-track in vivo preclinical immunotherapy development
  • Screen compounds across well-validated panels of syngeneic and tumor homograft models
  • Benefit from Crown Bioscience covering the cost of the vehicle group for all models 

Learn More about MuScreen

Leverage Our Multiomics Biomarker Analysis Platform

Comprehensive multiomics biomarker analysis allows researchers to gain a more complete understanding of the molecular changes that underlie a particular disease or during the response to certain treatment. 

At Crown Bioscience, we continually invest in cutting-edge technologies, and validate and develop new assays, to provide our customers with a comprehensive range of multi-omics laboratory services. 

Rely on our flexible methodologies, extensive experience, well-established and validated workflows, highly specialized bioinformatics teams, wide collection of historical data, high-quality, and fast turnaround, to empower your preclinical drug development. 

Discover more about our comprehensive multiomics biomarker analysis platform: 

Learn More about Our Lab Services

Bioinformatics Data Analysis for Biomarker Discovery

Trust our extensive experience and powerful bioinformatics capabilities to maximize the value of your preclinical data, and de-risk your drug development through early identification of candidate biomarkers. Use our biomarker discovery services to advance your preclinical and clinical therapeutic candidates with:

  • In-depth biological insight into mechanisms of action and pharmacodynamics
  • Enhanced trial design and patient stratification through data-informed trial decisions
  • Improved clinical trial success using predictive or prognostic biomarkers

 

Biomarkers of Response: HuMark™

Understand the relationships between genes, protein expression, molecular interactions and activity that define the fundamental components of a predictive biomarkers.

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Biomarker Discovery and Companion Diagnostics

De-risk your therapeutic development through early identification of candidate biomarkers and clinical evaluation of companion diagnostics.

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Mouse Clinical Trials: HuTrial™

Identify responders, partial responders and non-responders with mouse clinical trials to help stratify patients before you enter the clinic.

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Signatures of Response: HuSignature™

Explore a proprietary genetic signature discovery and validation platform, allowing higher identification probability of response to your molecule.

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Utilize Our Complimentary Tumor Model Databases To Quickly Find Models to Fit Your Research Needs

Discover more about our searchable databases with wide coverage of preclinical tumor models:

Comprehensive data available in the databases

Get Free Access to the Cancer Model Databases

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