Immune Monitoring

The immune system plays a vital role in defending the body against disease, and many drugs are designed to target the immune system to treat conditions such as cancer, autoimmune disorders, and infectious diseases. By understanding and monitoring the immune systems response to a drug, researchers can potentially develop more effective and safer drugs to improve patient outcomes.

Applications of Immune Monitoring:

Evaluate the safety of a drug candidate. Many drug candidates trigger an immune response that can cause adverse reactions, such as allergies, hypersensitivity, cytokine storm, or autoimmune disorders. By monitoring the immune response of a drug candidate, researchers can identify potential safety issues early in the development process, allowing them to modify their molecule accordingly.

Determine the efficacy of a drug candidate. Many drug candidates that target the immune system have off-target effects or trigger an incomplete immune response. By monitoring the immune response, researchers can evaluate whether the drug candidate is effectively modulating the immune response and fighting the disease.

Establish preferred patient populations. Immune responses are complex and can be influenced by various factors, including genetics, environmental factors, and comorbidities. Monitoring the immune response allows researchers to identify patient subgroups that may respond differently to the drug candidate and adjust the molecule's dose, regimen, or formulation to improve its effectiveness.

Identify potential biomarkers of drug response. Biomarkers can be used to predict whether a drug candidate will be effective in treating a particular disease or patient population. Researchers can identify potential biomarkers that can be used to predict which patients will respond to the drug and optimize patient selection by monitoring the immune response of their drug candidate

We offer a wide collection of immune monitoring assays, including some unique services. Rely on our immunological expertise, broad capabilities, flexibility to customize assays to your special needs, quick turnaround, and cost-efficient services to accelerate your drug development:

• Whole transcriptome profiling with RNA sequencing
• Immune-targeting RNA sequencing
  • • Mouse I/O RNA-Seq panel
• Flow Cytometry
  • Immune Cell Activation Assay
  • Immuno-phenotyping
  • T Cell Proliferation Assay
  • Receptor Occupancy
  • Cytotoxicity
  • Cellular Immune response
  • Immunogenicity
• Cytokine and chemokine profiling
• Digital Pathology
• ELISA and Multiplex Immunoassays:
  
  • Cellular Immune response
  • Humoral Immune Response (T cell dependent antibody response, TDAR)
  • Immunogenicity
• Antibody-dependent Cell-mediated Cytotoxicity (ADCC) Assays
• Functional Assays