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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Tissue

Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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KRAS

Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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EGFR

Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Bioinformatics

Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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CRISPR/Cas9

Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Genomics

Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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Biomarker Discovery

De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Laboratory Services

Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.

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Pharmacology & Bioanalytical Services

Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Screens

Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Toxicology

Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Our Company

Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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Our Purpose

Learn more about the impact we make through our scientific talent, high-quality standards, and innovation.

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Our Responsibility

We build a sustainable future by supporting employee growth, fostering leadership, and exceeding customer needs. Our values focus on innovation, social responsibility, and community well-being.

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Meet Our Leadership Team

We build a sustainable future by fostering leadership, employee growth, and exceeding customer needs with innovation and social responsibility.

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Scientific Advisory Board

Our Scientific Advisory Board of experts shapes our strategy and ensures top scientific standards in research and development.

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News & Events

Stay updated with Crown Bioscience's latest news, achievements, and announcements. Check our schedule for upcoming events and plan your visit.

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Career Opportunities

Join us for a fast-paced career addressing life science needs with innovative technologies. Thrive in a respectful, growth-focused environment.

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Scientific Publications

Access our latest scientific research and peer-reviewed articles. Discover cutting-edge findings and insights driving innovation and excellence in bioscience.

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Resources

Discover valuable insights and curated materials to support your R&D efforts. Explore the latest trends, innovations, and expertly curated content in bioscience.

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Blogs

Explore our blogs for the latest insights, research breakthroughs, and industry trends. Stay educated with expert perspectives and in-depth articles driving innovation in bioscience.

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  • Platforms
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Digital Pathology

A morphology, imaging & pathology-based biomarker analysis platform

Rapidly understand your drug’s mechanism and effect through automated immunohistochemistry and immunofluorescence staining and digital analysis. Comprehensive tissue histology characterization from our stringently validated histology platform allows you to save time without compromising accuracy with our well-validated digital pathology platform to ensure high quality analysis of your preclinical and non-CLIA regulated samples:

Digital Pathology Platform


  • Accelerate your research with our selection of over 400 IHC validated markers and multiplex panels for fast and accurate analysis.
  • Streamline your workflow with our integrated digital pathology platform, offering:

    • Automated staining with Leica BOND RX and Roche Ventana BenchMark ULTRA.
    • High-throughput imaging via Akoya Biosciences’ PhenoImager® HT and 3DHISTECH Pannoramic Scan.
    • Detailed tissue analysis with the HALO® image analysis platform, featuring real-time data sharing and remote review capabilities with HALO Link.
  • Count on our thorough validation and QC process for consistent and reliable data.
  • Draw on our immunology and immuno-oncology expertise using translational tumor models based biomarker analysis to gain insights into the tumor microenvironment and the efficacy of cancer treatments.

Download validated markers and panels list

DISCOVER OUR TUMOR TISSUE MICROARRAY COLLECTION


examples_digital_pathology

Akoya Biosciences’ PhenoImager® HT

Advanced Multispectral Imaging (MSI) Technology

PhenoImager® HT (formerly Vectra® Polaris™) is the fastest and most highly cited whole-slide, single-cell resolution imaging platform for spatial phenotyping and the development of spatial signatures. Featuring Akoya’s patented Multispectral Imaging (MSI) and spectral unmixing technologies, this platform can be easily integrated into high-throughput workflows to accommodate projects regardless of your scale.


Figure. PD-L1-Immune Panel--Human Tonsil

How PhenoImager HT Works:

  • Multispectral Unmixing: It discerns specific biomarkers from autofluorescence and overlapping signals.
  • High-Throughput Workflow: From custom assay development to multiplex imaging, brightfield and fluorescence imaging up to 9 colors.
  • Automation: The PhenoImager HT offers a fully enclosed system with touchless slide handling for a streamlined workflow.

Benefits at a Glance:

  • Clarity and Precision: The technology unmasks up to 8 biomarkers simultaneously, providing clear, quantifiable insights without autofluorescence interference.
  • Speed and Scale: Conduct comprehensive 6-plex whole slide scans in under 20 minutes with an 80 slide capacity, bolstering high-throughput operations.
  • Versatile Imaging: Whether it's immunofluorescent or immunohistochemical stains, the PhenoImager HT delivers detailed images across a range of staining techniques.

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