<img height="1" width="1" src="https://www.facebook.com/tr?id=1582471781774081&amp;ev=PageView &amp;noscript=1">
  • Menu
  • crown-logo-symbol-1-400x551

Find it Quickly

Get Started

Select the option that best describes what you are looking for

  • Services
  • Models
  • Scientific Information

Search Here For Services

Click Here to Start Over

Search Here For Models

Click Here to Start Over

Search Here For Scientific Information

Click Here to Start Over

In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

Learn More

In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

Learn More

Tissue

Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

Learn More

Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

Learn More

Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

Learn More

KRAS

Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

Learn More

EGFR

Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

Learn More

Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

Learn More

Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

Learn More

Bioinformatics

Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

Learn More

Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

Learn More

CRISPR/Cas9

Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

Learn More

Genomics

Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

Learn More

In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

Learn More

Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

Learn More

Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

Learn More

Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

Learn More

Biomarker Discovery

De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

Learn More

DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

Learn More

Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

Learn More

Laboratory Services

Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.

Learn More

Pharmacology & Bioanalytical Services

Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

Learn More

Screens

Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

Learn More

Toxicology

Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

Learn More

Our Company

Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

Learn More

Our Purpose

Learn more about the impact we make through our scientific talent, high-quality standards, and innovation.

Learn More

Our Responsibility

We build a sustainable future by supporting employee growth, fostering leadership, and exceeding customer needs. Our values focus on innovation, social responsibility, and community well-being.

Learn More

Meet Our Leadership Team

We build a sustainable future by fostering leadership, employee growth, and exceeding customer needs with innovation and social responsibility.

Learn More

Scientific Advisory Board

Our Scientific Advisory Board of experts shapes our strategy and ensures top scientific standards in research and development.

Learn More

News & Events

Stay updated with Crown Bioscience's latest news, achievements, and announcements. Check our schedule for upcoming events and plan your visit.

Learn More

Career Opportunities

Join us for a fast-paced career addressing life science needs with innovative technologies. Thrive in a respectful, growth-focused environment.

Learn More

Scientific Publications

Access our latest scientific research and peer-reviewed articles. Discover cutting-edge findings and insights driving innovation and excellence in bioscience.

Learn More

Resources

Discover valuable insights and curated materials to support your R&D efforts. Explore the latest trends, innovations, and expertly curated content in bioscience.

Learn More

Blogs

Explore our blogs for the latest insights, research breakthroughs, and industry trends. Stay educated with expert perspectives and in-depth articles driving innovation in bioscience.

Learn More

  • Platforms
  • Target Solutions
  • Technologies
  • Service Types
Background Image

Biofluid Testing

Hematology analysis, bio fluid chemistry, and biomarker services

Our non-GLP biofluid tests provide robust, high-quality data for early-stage preclinical drug development. These services provide a rapid, cost-effective way to analyze blood and urine samples as a standalone service, or supplementary to in vivo studies.

Analytes listed in the following sections are subject to change. Please contact your local business development specialist for our current offerings. Additional assays are available with a validation lead time of approximately 2-3 weeks.

Blood and Urine Chemistry Analysis

Gain valuable information about drug efficacy, candidate selection, MoA, and enzymatic activity using a comprehensive portfolio of clinical chemistry assays developed on the Beckman Coulter® AU480 Chemistry Analyzer and Sysmex BX-3010 Automatic Chemistry Analyzer.

Blood and Urine Chemistry Analysis Sample Panel

 
Alanine aminotransferase (ALT) Hemoglobin A1C (HBA1c)
Aspartate aminotransferase (AST) Homocysteine
Albumin (ALB) Ion-specific electrode (ISE: Na, K, CL)
Alkaline Phosphatase (ALP) Iron
Beta-2-Microglobulin (B2M) Lactate dehydrogenase (LDH)
Bicarbonate (CO2) LDL Cholesterol
Calcium Lipemia, Icterus, Hemolysis (LIH)
Cholesterol Lipase
C-Reactive Protein (CRP) Magnesium
Creatine Kinase Urine Total Protein (MTP)
Creatinine Phosphorus
CYSC Total Bilirubin
Direct Bilirubin Triglyceride
GGT (Gamma-Glutamyltransferase) Urea Nitrogen (BUN)
Glucose Uric Acid
HDL Cholesterol Urine Albumin


Complete Blood Count (CBC)

Platform:

  • Element HT5 Veterinary Hematology Analyzer
  • VETSCAN ® HM5 Hematology Analyzer

Complete Blood Count Sample Panel

 
White Blood Cell Count (WBC)
Lymphocytes (LYM)
Monocytes (MON)
Neutrophils (NEU)
Percentage of White Blood Cells (WBC%)
Percentage of Lymphocytes (LYM%)
Percentage of Monocytes (MON%)
Percentage of Neutrophils (NEU%)
Red Blood Cell Count (RBC)
Hematocrit (HCT)
Mean Corpuscular Volume (MCV)
Red Cell Distribution Width (coefficient of variation) (RDWc)
Red Cell Distribution Width (standard deviation) (RDWs)
Hemoglobin (HGB)
Mean Corpuscular Hemoglobin (MCH)
Mean Corpuscular Hemoglobin Concentration (MCHC)
Platelet Count (PLT)
Mean Platelet Volume (MPV)
Platelet Crit (PCT)
Platelet Distribution Width (coefficient of variation) (PDWc)
Platelet Distribution Width (standard deviation) (PDWs)

Biomarker Analysis Services

Translational biomarkers are used throughout drug development to help elucidate underlying pathophysiology, understand an agents’ mechanism of action, measure efficacy, and stratify patient populations. We provide a panel of routinely performed immunoassay services to inform decision-making in drug development, as well as developing, validating, and performing custom assays.


Meso Scale Discovery® (MSD) Biomarker Assays

Run your samples on MSD’s electrochemiluminescence technology platform. Using the Sector S 600, biomarkers can be customized into a V-PLEX or U-PLEX plate with up to 10 biomarkers of your choice.

MSD Assay Sample Panel

 
Rodent Assays Human and Nonhuman Primate Assays
(NHP Valided Kits)
Mouse Adiponectin 4-Spot Prototype Human Insulin, C-Peptide for NHP
Mouse IL-1b Human/NHP Glucagon
Mouse IL-2 Human/NHP Adiponectin
Mouse IL-4 Human/NHP Total GIP
Mouse IL-5 Human/NHP Insulin
Mouse IL-6 NHP Total GLP-1 (ver. 2 Kit)
Mouse IL-10  
Mouse Leptin  
Mouse MIP-3a  
Mouse Pro-inflammatory 7plex, tissue culture  
Mouse Pro-inflammatory Panel 1
(IFN-ץ, IL-1β, IL-2, IL-4, IL-5, IL-6, KC/GRO, IL-10, IL-12p70 and TNF-α)
 
Mouse TGFB1  
Mouse TNF-a  
Mouse/Rat GLP-1 (7-36 amide)  
Mouse/Rat Glucagon  
Mouse/Rat Insulin  
Mouse/Rat Insulin/Glucagon  
Mouse/Rat Total Active GLP1, Insulin, Glucagon  
Mouse/Rat Total GLP-1  
Rat BNP  
Rat IL-1a  
Rat IL-1b  
Rat IL-4  
Rat IL-5  
Rat IL-6  
Rat IL-13  
Rat Kidney Injury Panel 1
(Urine Albumin, KIM-1, NGAL/LCN2, Osteopontin)
 
Rat MCP-1  
Rat Pro-inflammatory Panel 2
(IFN-γ, IL-10, IL-13, IL-1β, IL-4, IL-5, IL-6, KC/GRO, TNF-α)
 
Rat TNF-a  


Colorimetric ELISA Biomarker Assays

Evaluate biomarkers on our standard, colorimetric, enzyme-based ELISA platform.

ELISA Assay Sample Panel

 
Rodent Assays Human and NHP Assays
Mouse Hydroxyproline Human Cortisol
Mouse Urine Albumin Human IGFBP-1
Mouse/Rat Corticosterone Human STELLUX Chemi Insulin
Mouse/Rat/Human Free Glycerol  
Rat Alpha-Fetoprotein  
Rat Fecal Corticosterone Cayman  
Rat Growth Hormone  
Rat TGFB1  
Rat Urine Albumin  
Rodent STELLUX Chemi Insulin  


Service Details

Turn Around Time: 5-7 business days (clinical chemistry), 7-10 business days (MSD & ELISA) Data Delivery Format: Excel File, unless otherwise requested

Assay Validation

To ensure you receive reliable data, we perform rigorous quality control and assay qualification procedures to ensure precision and accuracy. Our high quality results enable you to make preclinical go/no-go decisions with confidence.

Crown Bioscience's custom-fit, 7-point standard curves used to calculate accurate and precise concentrations for IL-10 and TNF-α.

Talk to an expert about your project

We are here to help!

Get In Touch